Cutaneous wounds are a growing global health burden as a result of an aging population
coupled with increasing incidence of diabetes, obesity, and cancer. Cell-based approaches …

Vascular smooth muscle cells (SMCs) arise from multiple origins during development,
raising the possibility that differences in embryological origins between SMCs could …

Totipotency is the ability of a single cell to give rise to all of the differentiated cell types that
build the conceptus, yet how to capture this property in vitro remains incompletely …

Cell surface proteins are major targets of biomedical research due to their utility as cellular
markers and their extracellular accessibility for pharmacological intervention. However …

The in vitro generation of germ cells from pluripotent stem cells (PSCs) can have a
substantial effect on future reproductive medicine and animal breeding. A decade ago, in …

Embryonic stem cells (ESCs) are derived from mammalian embryos during the transition
from totipotency, when individual blastomeres can make all lineages, to pluripotency, when …

Flow cytometry is used increasingly in clinical research for cancer, immunology and
vaccines. Technological advances in cytometry instrumentation are increasing the size and …

Abstract PDX1+/NKX6-1+ pancreatic progenitors (PPs) give rise to endocrine cells both in
vitro and in vivo. This cell population can be successfully differentiated from human …

Mammalian preimplantation development involves two lineage specifications: first, the
CDX2-expressing trophectoderm (TE) and a pluripotent inner cell mass (ICM) are separated …

Spatially ordered embryo-like structures self-assembled from blastocyst-derived stem cells
can be generated to mimic embryogenesis in vitro. However, the assembly system and …