Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …

Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …

The intestinal epithelium withstands continuous mechanical, chemical and biological insults
despite its single-layered, simple epithelial structure. The crypt–villus tissue architecture in …

Colorectal cancers (CRCs) arise from precursor polyps whose cellular origins, molecular
heterogeneity, and immunogenic potential may reveal diagnostic and therapeutic insights …

A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions
between luminal contents such as the intestinal microbiota, the underlying immune system …

BACKGROUND In adult mammalian organisms, multiple tissues—including the skin, blood,
stomach, and intestines—are entrapped in a state of permanent regeneration; older cells are …

Small populations of adult stem cells are responsible for the remarkable ability of the
epithelial lining of the intestine to be efficiently renewed and repaired throughout life. The …

Due to its intense self-renewal kinetics and its simple repetitive architecture, the intestinal
epithelium has become a prime model for studying adult stem cells in health and disease …

Importance Metastatic colorectal cancer (mCRC) is heterogeneous, and primary tumors
arising from different regions of the colon are clinically and molecularly distinct. Objective To …

Recent examples have highlighted how stem cells have the capability to initiate
morphogenesis in vitro; that is, to generate complex structures in culture that closely parallel …