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Genetic and biological hallmarks of colorectal cancer
Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …
tumors, and these insights have illuminated early detection, risk stratification, prevention …
Cell fate specification and differentiation in the adult mammalian intestine
Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …
[HTML][HTML] Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps
Colorectal cancers (CRCs) arise from precursor polyps whose cellular origins, molecular
heterogeneity, and immunogenic potential may reveal diagnostic and therapeutic insights …
heterogeneity, and immunogenic potential may reveal diagnostic and therapeutic insights …
Hallmarks of stemness in mammalian tissues
All adult tissues experience wear and tear. Most tissues can compensate for cell loss
through the activity of resident stem cells. Although the cellular maintenance strategies vary …
through the activity of resident stem cells. Although the cellular maintenance strategies vary …
Tales from the crypt: new insights into intestinal stem cells
The intestinal epithelium withstands continuous mechanical, chemical and biological insults
despite its single-layered, simple epithelial structure. The crypt–villus tissue architecture in …
despite its single-layered, simple epithelial structure. The crypt–villus tissue architecture in …
Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell
The turnover of the intestinal epithelium is driven by multipotent LGR5+ crypt-base columnar
cells (CBCs) located at the bottom of crypt zones. However, CBCs are lost following injury …
cells (CBCs) located at the bottom of crypt zones. However, CBCs are lost following injury …
Molecular pathogenesis, targeted therapies, and future perspectives for gastric cancer
Gastric cancer is a major source of global cancer mortality with limited treatment options and
poor patient survival. As our molecular understanding of gastric cancer improves, we are …
poor patient survival. As our molecular understanding of gastric cancer improves, we are …
Transfer of functional cargo in exomeres
Exomeres are a recently discovered type of extracellular nanoparticle with no known
biological function. Herein, we describe a simple ultracentrifugation-based method for …
biological function. Herein, we describe a simple ultracentrifugation-based method for …
The intestinal epithelial barrier: a therapeutic target?
A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions
between luminal contents such as the intestinal microbiota, the underlying immune system …
between luminal contents such as the intestinal microbiota, the underlying immune system …
Cell biology of tight junction barrier regulation and mucosal disease
Mucosal surfaces are lined by epithelial cells. In the intestine, the epithelium establishes a
selectively permeable barrier that supports nutrient absorption and waste secretion while …
selectively permeable barrier that supports nutrient absorption and waste secretion while …