Biological effect of protein modifications by lipid peroxidation products

A Gęgotek, E Skrzydlewska - Chemistry and physics of lipids, 2019 - Elsevier
The products of lipid peroxidation, resulting from cell metabolism as well as the action of
external physical factors and xenobiotics, have a significant impact on cell functions. One of …

Lipid peroxidation in atherosclerotic cardiovascular diseases

E Gianazza, M Brioschi… - Antioxidants & redox …, 2021 - liebertpub.com
Significance: Atherosclerotic cardiovascular diseases (ACVDs) continue to be a primary
cause of mortality worldwide in adults aged 35–70 years, occurring more often in countries …

[HTML][HTML] On the role of 4-hydroxynonenal in health and disease

M Csala, T Kardon, B Legeza, B Lizák, J Mandl… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Polyunsaturated fatty acids are susceptible to peroxidation and they yield various
degradation products, including the main α, β-unsaturated hydroxyalkenal, 4-hydroxy-2, 3 …

Mitochondrial reactive oxygen species at the heart of the matter: new therapeutic approaches for cardiovascular diseases

OS Kornfeld, S Hwang, MH Disatnik, CH Chen… - Circulation …, 2015 - Am Heart Assoc
Reactive oxygen species (ROS) have been implicated in a variety of age-related diseases,
including multiple cardiovascular disorders. However, translation of ROS scavengers …

Electrophilic aldehyde 4-hydroxy-2-nonenal mediated signaling and mitochondrial dysfunction

S Sharma, P Sharma, T Bailey, S Bhattarai, U Subedi… - Biomolecules, 2022 - mdpi.com
Reactive oxygen species (ROS), a by-product of aerobic life, are highly reactive molecules
with unpaired electrons. The excess of ROS leads to oxidative stress, instigating the …

[HTML][HTML] SOD2 deficiency in cardiomyocytes defines defective mitochondrial bioenergetics as a cause of lethal dilated cardiomyopathy

S Sharma, S Bhattarai, H Ara, G Sun, DK St Clair… - Redox biology, 2020 - Elsevier
Abstract Electrophilic aldehyde (4-hydroxynonenal; 4-HNE), formed after lipid peroxidation,
is a mediator of mitochondrial dysfunction and implicated in both the pathogenesis and the …

Interrelationship of lipid aldehydes (MDA, 4-HNE, and 4-ONE) mediated protein oxidation in muscle foods

Y Huang, S Sarkhel, A Roy, A Mohan - Critical Reviews in Food …, 2024 - Taylor & Francis
Proteins and essential fatty acids are crucial components of the human diet. However, lipids
and proteins are susceptible to oxidative modification during food processing resulting in …

Lipid oxidation derived aldehydes and oxysterols between health and disease

B Sottero, G Leonarduzzi, G Testa… - European journal of …, 2019 - Wiley Online Library
Non‐enzymatic and enzymatic oxidation of lipids has long been a primary issue in human
pathophysiology, with special emphasis on diet‐and nutrition‐related aspects. While there is …

Effect of zearalenone-induced ferroptosis on mice spermatogenesis

Y Li, Z Zhu, H Cui, K Ding, Y Zhao, X Ma, AO Adetunji… - Animals, 2022 - mdpi.com
Simple Summary Zearalenone is a mycotoxin that can cause reproductive toxicity after long-
term feeding in domestic animals and it affects spermatogenesis in male domestic animals …

[HTML][HTML] Ketogenic diets composed of long-chain and medium-chain fatty acids induce cardiac fibrosis in mice

F Sternberg, C Sternberg, A Dunkel, T Beikbaghban… - Molecular …, 2023 - Elsevier
Purpose Heart diseases are the leading cause of death worldwide. Metabolic interventions
via ketogenic diets (KDs) have been used for decades to treat epilepsy, and more recently …