The immune response during acute HIV-1 infection: clues for vaccine development
AJ McMichael, P Borrow, GD Tomaras… - Nature Reviews …, 2010 - nature.com
The early immune response to HIV-1 infection is likely to be an important factor in
determining the clinical course of disease. Recent data indicate that the HIV-1 quasispecies …
determining the clinical course of disease. Recent data indicate that the HIV-1 quasispecies …
Animal models for HIV/AIDS research
T Hatziioannou, DT Evans - Nature Reviews Microbiology, 2012 - nature.com
The AIDS pandemic continues to present us with unique scientific and public health
challenges. Although the development of effective antiretroviral therapy has been a major …
challenges. Although the development of effective antiretroviral therapy has been a major …
Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
SG Hansen, JC Ford, MS Lewis, AB Ventura… - Nature, 2011 - nature.com
The acquired immunodeficiency syndrome (AIDS)-causing lentiviruses human
immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) effectively evade …
immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) effectively evade …
HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcome
DZ Soghoian, H Jessen, M Flanders… - Science translational …, 2012 - science.org
Early immunological events during acute HIV infection are thought to fundamentally
influence long-term disease outcome. Whereas the contribution of HIV-specific CD8 T cell …
influence long-term disease outcome. Whereas the contribution of HIV-specific CD8 T cell …
A live-attenuated RhCMV/SIV vaccine shows long-term efficacy against heterologous SIV challenge
SG Hansen, EE Marshall, D Malouli… - Science translational …, 2019 - science.org
Previous studies have established that strain 68-1–derived rhesus cytomegalovirus
(RhCMV) vectors expressing simian immunodeficiency virus (SIV) proteins (RhCMV/SIV) are …
(RhCMV) vectors expressing simian immunodeficiency virus (SIV) proteins (RhCMV/SIV) are …
Rational antibody-based HIV-1 vaccine design: current approaches and future directions
LM Walker, DR Burton - Current opinion in immunology, 2010 - Elsevier
Many antiviral vaccines elicit neutralizing antibodies as a correlate of protection. For HIV,
given the huge variability of the virus, it is widely believed that the induction of a broadly …
given the huge variability of the virus, it is widely believed that the induction of a broadly …
TRIM5 Suppresses Cross-Species Transmission of a Primate Immunodeficiency Virus and Selects for Emergence of Resistant Variants in the New Species
A Kirmaier, F Wu, RM Newman, LR Hall… - PLoS …, 2010 - journals.plos.org
Simian immunodeficiency viruses of sooty mangabeys (SIVsm) are the source of multiple,
successful cross-species transmissions, having given rise to HIV-2 in humans, SIVmac in …
successful cross-species transmissions, having given rise to HIV-2 in humans, SIVmac in …
ADCC Develops Over Time during Persistent Infection with Live-Attenuated SIV and Is Associated with Complete Protection against SIVmac251 Challenge
MD Alpert, JD Harvey, WA Lauer, RK Reeves… - 2012 - journals.plos.org
Live-attenuated strains of simian immunodeficiency virus (SIV) routinely confer apparent
sterilizing immunity against pathogenic SIV challenge in rhesus macaques. Understanding …
sterilizing immunity against pathogenic SIV challenge in rhesus macaques. Understanding …
Fitness costs and diversity of the cytotoxic T lymphocyte (CTL) response determine the rate of CTL escape during acute and chronic phases of HIV infection
ABSTRACT HIV-1 often evades cytotoxic T cell (CTL) responses by generating variants that
are not recognized by CTLs. We used single-genome amplification and sequencing of …
are not recognized by CTLs. We used single-genome amplification and sequencing of …
New paradigms for HIV/AIDS vaccine development
HIV-1 and its simian counterpart SIV have been exquisitely tailored by evolution to evade
host immunity. By virtue of specific adaptations that thwart individual innate or adaptive …
host immunity. By virtue of specific adaptations that thwart individual innate or adaptive …