Background: This review summarizes data on heterocyclic systems with thiadiazole and
thiazole fragments in molecules as promising antimicrobial agents. Introduction: Thiadiazole …

Topoisomerases II are ubiquitous enzymes with significant genotoxic effects in many critical
DNA processes. Additionally, epidermal growth factor receptor (EGFR) plays pivotal role in …

A new series of triazolopyrimidines and thiazolopyrimidine hydrobromides was designed
and prepared as topoisomerase II inhibitors. Screening of all synthesized compounds was …

The review considers in detail methods of synthesis of thiazolo [3, 2-a] pyrimidines,
synthesis and chemical properties of their 2-substituted derivatives, and crystal structures of …

Antimicrobial resistance is one of the biggest threats to public health across the globe.
Bacteria, fungi, viruses, and protozoans have been exhibiting resistance against …

A series of novel azacalix [2] arene [2] pyrimidines were synthesized, and evaluated for their
antiproliferative activities against A549, MCF7, SH-SY5Y and CNE human cancer cell lines …

A new series of thiazolo [3, 2-a] pyrimidine bromide salt derivatives 7a–d were synthesized
from 3, 4-dihydropyrimidinethione precursors. The target compounds were fully …

Triazolo [4, 3-a] pyrimidines were prepared by the reduction of 5, 6, 7-trisubstituted 2-
(arylhydrazinylidene)-5 H-[1, 3] thiazolo [3, 2-a]-pyrimidin-3 (2 H)-ones with NaBH 4 in the …

Background: Thiazolopyrimidine derivatives containing bridgehead nitrogen atom are nowa-
days attracting the attention of many medicinal chemists throughout the world to explore this …

A series of new thiazolopyrimidine analogues were conveniently synthesized by one-pot
multicomponent condensation reaction of ethyl acetoacetate, 2-aminothiazole and …