The major function of the placenta is to transfer nutrients and oxygen from the mother to the
foetus and to assist in the removal of waste products from the foetus to the mother. In …

Dual 5-LOX/COX inhibitors are potential new drugs to treat inflammation. They act by
blocking the formation of both prostaglandins and leucotrienes but do not affect lipoxin …

OBJECTIVES: The involvement of an immune process in the pathophysiology of major
depression disorder (MDD) was substantiated by studies demonstrating elevated levels of …

Arachidonic acid (ARA) undergoes enzyme-mediated oxidative metabolism, resulting in the
formation of a number of biologically active metabolites. For over a century, these …

Drugs able to inhibit both cyclooxygenases (COX-1 and COX-2) and 5-lipoxygenase (5-
LOX)(dual acting anti-inflammatory drugs) have been designed in order to obtain …

Prostaglandin E2 (PGE2) is an endogenous lipid molecule involved in normal brain
development. Cyclooxygenase‐2 (COX2) is the main regulator of PGE2 synthesis. Emerging …

Abstract 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD), a potent environmental contaminant,
is an endocrine disrupter with a proven reproductive toxicity in mammals. However, its …

Many small molecules (mostly lipids derived from polyunsaturated fatty acids) and proteins
(eg, cytokines and chemokines) are labeled as inflammatory mediators for their role in …

purpose. Cyclooxygenases (COX) orchestrate a variety of homeostatic processes and
participate in various pathophysiological conditions. The retinal pigment epithelium (RPE) …

Cyclooxygenase-3 (COX-3), a new acetaminophen-sensitive isoform of the COX family, has
recently been cloned from canine tissues. Canine COX-3 apparently is identical to the full …