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The burden and risks of emerging complications of diabetes mellitus
The traditional complications of diabetes mellitus are well known and continue to pose a
considerable burden on millions of people living with diabetes mellitus. However, advances …
considerable burden on millions of people living with diabetes mellitus. However, advances …
Dementia prevention, intervention, and care: 2020 report of the Lancet Commission
Executive summary The number of older people, including those living with dementia, is
rising, as younger age mortality declines. However, the age-specific incidence of dementia …
rising, as younger age mortality declines. However, the age-specific incidence of dementia …
Prediabetes and risk of mortality, diabetes-related complications and comorbidities: umbrella review of meta-analyses of prospective studies
S Schlesinger, M Neuenschwander, J Barbaresko… - Diabetologia, 2022 - Springer
Aims/hypothesis The term prediabetes is used for individuals who have impaired glucose
metabolism whose glucose or HbA 1c levels are not yet high enough to be diagnosed as …
metabolism whose glucose or HbA 1c levels are not yet high enough to be diagnosed as …
Association between age at diabetes onset and subsequent risk of dementia
Importance Trends in type 2 diabetes show an increase in prevalence along with younger
age of onset. While vascular complications of early-onset type 2 diabetes are known, the …
age of onset. While vascular complications of early-onset type 2 diabetes are known, the …
Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications
Cognitive dysfunction is increasingly recognized as an important comorbidity of diabetes
mellitus. Different stages of diabetes-associated cognitive dysfunction exist, each with …
mellitus. Different stages of diabetes-associated cognitive dysfunction exist, each with …
Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
Considerable overlap has been identified in the risk factors, comorbidities and putative
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …
Exercise benefits on Alzheimer's disease: State-of-the-science
Although there is no unanimity, growing evidence supports the value of regular physical
exercise to prevent Alzheimer's disease as well as cognitive decline in affected patients …
exercise to prevent Alzheimer's disease as well as cognitive decline in affected patients …
Sex differences in the burden of type 2 diabetes and cardiovascular risk across the life course
By 2017 estimates, diabetes mellitus affects 425 million people globally; approximately 90–
95% of these have type 2 diabetes. This narrative review highlights two domains of sex …
95% of these have type 2 diabetes. This narrative review highlights two domains of sex …
The effects of genetic and modifiable risk factors on brain regions vulnerable to ageing and disease
We have previously identified a network of higher-order brain regions particularly vulnerable
to the ageing process, schizophrenia and Alzheimer's disease. However, it remains …
to the ageing process, schizophrenia and Alzheimer's disease. However, it remains …
[HTML][HTML] The brain as an insulin-sensitive metabolic organ
Background The brain was once thought of as an insulin-insensitive organ. We now know
that the insulin receptor is present throughout the brain and serves important functions in …
that the insulin receptor is present throughout the brain and serves important functions in …