Cannabinoid receptors and the endocannabinoid system: signaling and function in the central nervous system

S Zou, U Kumar - International journal of molecular sciences, 2018 - mdpi.com
The biological effects of cannabinoids, the major constituents of the ancient medicinal plant
Cannabis sativa (marijuana) are mediated by two members of the G-protein coupled …

From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology

A Ligresti, L De Petrocellis… - Physiological …, 2016 - journals.physiology.org
Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

The endocannabinoid system in guarding against fear, anxiety and stress

B Lutz, G Marsicano, R Maldonado… - Nature Reviews …, 2015 - nature.com
The endocannabinoid (eCB) system has emerged as a central integrator linking the
perception of external and internal stimuli to distinct neurophysiological and behavioural …

Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment

ME Ertunc, GS Hotamisligil - Journal of lipid research, 2016 - ASBMB
Lipids encompass a wide variety of molecules such as fatty acids, sterols, phospholipids,
and triglycerides. These molecules represent a highly efficient energy resource and can act …

Hypothalamic POMC neurons promote cannabinoid-induced feeding

M Koch, L Varela, JG Kim, JD Kim, F Hernández-Nuño… - Nature, 2015 - nature.com
Hypothalamic pro-opiomelanocortin (POMC) neurons promote satiety. Cannabinoid
receptor 1 (CB 1 R) is critical for the central regulation of food intake. Here we test whether …

[HTML][HTML] Oxytocin enhances social recognition by modulating cortical control of early olfactory processing

LL Oettl, N Ravi, M Schneider, MF Scheller… - Neuron, 2016 - cell.com
Oxytocin promotes social interactions and recognition of conspecifics that rely on olfaction in
most species. The circuit mechanisms through which oxytocin modifies olfactory processing …

A cannabinoid link between mitochondria and memory

E Hebert-Chatelain, T Desprez, R Serrat, L Bellocchio… - Nature, 2016 - nature.com
Cellular activity in the brain depends on the high energetic support provided by
mitochondria, the cell organelles which use energy sources to generate ATP,,,. Acute …

Genetics and epigenetics of eating disorders

Z Yilmaz, JA Hardaway, CM Bulik - Advances in genomics and …, 2015 - Taylor & Francis
Eating disorders (EDs) are serious psychiatric conditions influenced by biological,
psychological, and sociocultural factors. A better understanding of the genetics of these …

Principles of odor coding in vertebrates and artificial chemosensory systems

I Manzini, D Schild, C Di Natale - Physiological reviews, 2022 - journals.physiology.org
The biological olfactory system is the sensory system responsible for the detection of the
chemical composition of the environment. Several attempts to mimic biological olfactory …

Astroglial CB1 receptors determine synaptic D-serine availability to enable recognition memory

LM Robin, JFO da Cruz, VC Langlais… - Neuron, 2018 - cell.com
Bidirectional communication between neurons and astrocytes shapes synaptic plasticity and
behavior. D-serine is a necessary co-agonist of synaptic N-methyl-D-aspartate receptors …