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Immune checkpoint blockade in glioblastoma: from tumor heterogeneity to personalized treatment
Immune checkpoint blockade (ICB) has revolutionized modern cancer therapy, arousing
great interest in the neuro-oncology community. While several reports show that subsets of …
great interest in the neuro-oncology community. While several reports show that subsets of …
Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives
Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a
formidable challenge due to its immunosuppressive microenvironment, thereby confounding …
formidable challenge due to its immunosuppressive microenvironment, thereby confounding …
Ultrasound-mediated delivery of doxorubicin to the brain results in immune modulation and improved responses to PD-1 blockade in gliomas
Given the marginal penetration of most drugs across the blood-brain barrier, the efficacy of
various agents remains limited for glioblastoma (GBM). Here we employ low-intensity pulsed …
various agents remains limited for glioblastoma (GBM). Here we employ low-intensity pulsed …
[HTML][HTML] Microglia and brain macrophages as drivers of glioma progression
Evidence is accumulating that the tumour microenvironment (TME) has a key role in the
progression of gliomas. Non-neoplastic cells in addition to the tumour cells are therefore …
progression of gliomas. Non-neoplastic cells in addition to the tumour cells are therefore …
Pleiotropic effects of the COX-2/PGE2 axis in the glioblastoma tumor microenvironment
Glioblastoma (GBM) is the most common and aggressive form of malignant glioma. The
GBM tumor microenvironment (TME) is a complex ecosystem of heterogeneous cells and …
GBM tumor microenvironment (TME) is a complex ecosystem of heterogeneous cells and …
[HTML][HTML] Fluid dynamics in aging-related dementias
Recent human and animal model experimental studies revealed novel pathways for fluid
movement, immune cell trafficking and metabolic waste clearance in CNS. These studies …
movement, immune cell trafficking and metabolic waste clearance in CNS. These studies …
Tumor-associated macrophages correlate with prognosis in medulloblastoma
J Zhang, X Yuan, Y Wang, J Liu, Z Li, S Li, Y Liu… - Frontiers in …, 2022 - frontiersin.org
Purpose Macrophage polarization plays an essential role in the tumor microenvironment of
brain tumors. However, the role of tumor-associated macrophages (TAMs) in …
brain tumors. However, the role of tumor-associated macrophages (TAMs) in …
The tumor immune microenvironment in primary CNS neoplasms: a review of current knowledge and therapeutic approaches
Primary CNS neoplasms are responsible for considerable mortality and morbidity, and many
therapies directed at primary brain tumors have proven unsuccessful despite their success …
therapies directed at primary brain tumors have proven unsuccessful despite their success …
IRE1 endoribonuclease signaling promotes myeloid cell infiltration in glioblastoma
Background Intrinsic or environmental stresses trigger the accumulation of improperly folded
proteins in the endoplasmic reticulum (ER), leading to ER stress. To cope with this, cells …
proteins in the endoplasmic reticulum (ER), leading to ER stress. To cope with this, cells …
Myeloid cell classification and therapeutic opportunities within the glioblastoma tumor microenvironment in the single cell-omics era
The glioma tumor microenvironment (TME) is complex and heterogeneous, and multiple
emerging and current technologies are being utilized for an improved comprehension and …
emerging and current technologies are being utilized for an improved comprehension and …