Biocatalysis has undergone revolutionary progress in the past century. Benefited by the
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …

Natural products are widely employed in our daily lives as food additives, pharmaceuticals,
nutraceuticals, and cosmetic ingredients, among others. However, their supply has often …

Although biosynthetic gene clusters (BGCs) have been discovered for hundreds of bacterial
metabolites, our knowledge of their diversity remains limited. Here, we used a novel …

Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …

Metabolic engineering has the potential to produce from simple, readily available,
inexpensive starting materials a large number of chemicals that are currently derived from …

Prospecting macroalgae (seaweeds) as feedstocks for bioconversion into biofuels and
commodity chemical compounds is limited primarily by the availability of tractable …

The emergence of resistance to antibacterial agents is a pressing concern for human health.
New drugs to combat this problem are therefore in great demand, but as past experience …

For the past five decades, the need for new antibiotics has been met largely by
semisynthetic tailoring of natural product scaffolds discovered in the middle of the 20th …

Many drug candidates from marine and terrestrial invertebrates are suspected metabolites of
uncultured bacterial symbionts. The antitumor polyketides of the pederin family, isolated …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …