Role of estrogen receptors in health and disease

P Chen, B Li, L Ou-Yang - Frontiers in endocrinology, 2022 - frontiersin.org
Estrogen receptors (ERs) regulate multiple complex physiological processes in humans.
Abnormal ER signaling may result in various disorders, including reproductive system …

Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential

I Paterni, C Granchi, JA Katzenellenbogen, F Minutolo - Steroids, 2014 - Elsevier
Estrogen receptors alpha (ERα) and beta (ERβ) are nuclear transcription factors that are
involved in the regulation of many complex physiological processes in humans. Modulation …

Soy and health update: evaluation of the clinical and epidemiologic literature

M Messina - Nutrients, 2016 - mdpi.com
Soyfoods have long been recognized as sources of high-quality protein and healthful fat, but
over the past 25 years these foods have been rigorously investigated for their role in chronic …

Estrogens in male physiology

PS Cooke, MK Nanjappa, CM Ko… - Physiological …, 2017 - journals.physiology.org
Estrogens have historically been associated with female reproduction, but work over the last
two decades established that estrogens and their main nuclear receptors (ESR1 and ESR2) …

Benign prostatic hyperplasia–what do we know?

CM Devlin, MS Simms, NJ Maitland - BJU international, 2021 - Wiley Online Library
Objectives To present historical and contemporary hypotheses on the pathogenesis of
benign prostatic hyperplasia (BPH), and the potential implications for current medical …

Impact of estrogens in males and androgens in females

SR Hammes, ER Levin - The Journal of clinical …, 2019 - Am Soc Clin Investig
Androgens and estrogens are known to be critical regulators of mammalian physiology and
development. While these two classes of steroids share similar structures (in general …

Sexual dimorphism in cancer

A Clocchiatti, E Cora, Y Zhang, GP Dotto - Nature Reviews Cancer, 2016 - nature.com
The incidence of many types of cancer arising in organs with non-reproductive functions is
significantly higher in male populations than in female populations, with associated …

Androgens and estrogens in benign prostatic hyperplasia: past, present and future

TM Nicholson, WA Ricke - Differentiation, 2011 - Elsevier
Benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms (LUTS) are
common clinical problems in urology. While the precise molecular etiology remains unclear …

Estrogen receptors: therapies targeted to receptor subtypes

S Nilsson, JÅ Gustafsson - Clinical Pharmacology & …, 2011 - Wiley Online Library
Over the past two decades, we have learned that estrogens play important physiological
roles not only in women but also in men and that the biological effects of estrogen are …

Estrogen receptors and human disease: an update

KA Burns, KS Korach - Archives of toxicology, 2012 - Springer
A myriad of physiological processes in mammals are influenced by estrogens and the
estrogen receptors (ERs), ERα and ERβ. As we reviewed previously, given the widespread …