NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was
identified as a pivotal pathway in mediating inflammatory responses. However, with …

Lung cancer is a major global health problem, as it is the leading cause of cancer-related
deaths worldwide. Major advances in the identification of key mutational alterations have led …

Cancer immune evasion is a major stumbling block in designing effective anticancer
therapeutic strategies. Although considerable progress has been made in understanding …

NF-κB comprises a family of five transcription factors that form distinct protein complexes,
which bind to consensus DNA sequences at promoter regions of responsive genes …

Appreciation of the entire biological impact of an individual protein can be hampered by its
original naming based on one function only. Tissue inhibitor of metalloproteinases-1 (TIMP …

Tumor-derived protein tissue inhibitor of metalloproteinases-1 (TIMP1) correlates with poor
prognosis in many cancers, including highly lethal pancreatic ductal adenocarcinoma …

Matrix metalloproteinases (MMPs), a group of zinc-dependent endopeptidases involved in
the degradation of the extracellular matrix, play an important role in tissue remodeling …

Myocardial fibrosis is excess accumulation of the extracellular matrix fibrillar collagens.
Fibrosis is a key feature of various cardiomyopathies and compromises cardiac systolic and …

Tissue inhibitor of metalloproteinases-1 (TIMP-1) recently emerged as a pro-metastatic
factor highly associated with poor prognosis in a number of cancers. This correlation …

Deregulated NF-κB signalling is implicated in the pathogenesis of numerous human
inflammatory disorders and malignancies. Consequently, the NF-κB pathway has attracted …