Cancer stem cells (CSCs), a subpopulation of tumor cells, have self-renewal and multi-
lineage differentiation abilities that play an important role in cancer initiation, maintenance …

Autologous adoptive T-cell therapies have made tremendous strides over the last few years
with excitement currently being generated by technologies that can reprogram T-cell …

Tumor-associated immune cells have been discussed as an essential factor for the
prediction of the outcome of tumor patients. Lymphocyte-specific genes are associated with …

The AC133 epitope of CD133 is a cancer stem cell (CSC) marker for many tumor entities,
including the highly malignant glioblastoma multiforme (GBM). We have developed an …

Immunotherapy targeting checkpoint blockade to rescue T cells from exhaustion has
become an essential therapeutic strategy in treating cancers. Till now, little is known about …

Background The repetitive antigen stimulation during chronic infection often leads to the
accumulation of CD8+ CD57+ T cells. These cells express high levels of interferon-γ …

Purpose: Infusion of highly heterogeneous populations of autologous tumor-infiltrating
lymphocytes (TIL) can result in tumor regression of exceptional duration. Initial tumor …

Purpose: Improving our understanding of the immunologic response to cancer cells within
the sentinel lymph nodes (SLN) of primary tumors is expected to identify new approaches to …

Aging is considered the single most significant risk factor for the majority of common
malignances including lung cancer. Together immunosenescence, changes occurring with …

Incomplete differentiation of CD8+ cytotoxic T-lymphocytes (CTLs) in the tumor
microenvironment is associated with cancer progression. We describe a new type of tumor …