Immune system abnormalities in schizophrenia: an integrative view and translational perspectives

EA Ermakov, MM Melamud, VN Buneva… - Frontiers in …, 2022 - frontiersin.org
The immune system is generally known to be the primary defense mechanism against
pathogens. Any pathological conditions are reflected in anomalies in the immune system …

[HTML][HTML] Neuroinflammation in schizophrenia: the key role of the WNT/β-catenin pathway

A Vallée - International Journal of Molecular Sciences, 2022 - mdpi.com
Schizophrenia is a very complex syndrome involving widespread brain multi-
dysconnectivity. Schizophrenia is marked by cognitive, behavioral, and emotional …

Shedding light on biological sex differences and microbiota–gut–brain axis: a comprehensive review of its roles in neuropsychiatric disorders

P Shobeiri, A Kalantari, AL Teixeira, N Rezaei - Biology of sex differences, 2022 - Springer
Women and men are suggested to have differences in vulnerability to neuropsychiatric
disorders, including major depressive disorder (MDD), generalized anxiety disorder (GAD) …

Linking inflammation, aberrant glutamate-dopamine interaction, and post-synaptic changes: translational relevance for schizophrenia and antipsychotic treatment: a …

A de Bartolomeis, A Barone, L Vellucci, B Mazza… - Molecular …, 2022 - Springer
Evidence from clinical, preclinical, and post-mortem studies supports the
inflammatory/immune hypothesis of schizophrenia pathogenesis. Less evident is the link …

Biological hypotheses, risk factors, and biomarkers of schizophrenia

Z Fišar - Progress in neuro-psychopharmacology and Biological …, 2023 - Elsevier
Both the discovery of biomarkers of schizophrenia and the verification of biological
hypotheses of schizophrenia are an essential part of the process of understanding the …

Evidence-based umbrella review of 162 peripheral biomarkers for major mental disorders

AF Carvalho, M Solmi, M Sanches… - Translational …, 2020 - nature.com
The literature on non-genetic peripheral biomarkers for major mental disorders is broad, with
conflicting results. An umbrella review of meta-analyses of non-genetic peripheral …

Immunophenotypes in psychosis: is it a premature inflamm-aging disorder?

S Chen, Y Tan, L Tian - Molecular Psychiatry, 2024 - nature.com
Immunopsychiatric field has rapidly accumulated evidence demonstrating the involvement of
both innate and adaptive immune components in psychotic disorders such as …

Inflammation and nitro-oxidative stress in current suicidal attempts and current suicidal ideation: a systematic review and meta-analysis

A Vasupanrajit, K Jirakran, C Tunvirachaisakul… - Molecular …, 2022 - nature.com
A meta-analysis showed a significant association between activated immune-inflammatory
and nitro-oxidative (IO&NS) pathways and suicide attempts (SA). There is no data on …

Suicide attempts are associated with activated immune-inflammatory, nitro-oxidative, and neurotoxic pathways: A systematic review and meta-analysis

A Vasupanrajit, K Jirakran, C Tunvirachaisakul… - Journal of Affective …, 2021 - Elsevier
Background Suicide attempts (SA) frequently occur in patients with mood disorders and
schizophrenia, which are both accompanied by activated immune-inflammatory and nitro …