METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation

EA Orellana, Q Liu, E Yankova, M Pirouz… - Molecular cell, 2021 - cell.com
The emerging" epitranscriptomics" field is providing insights into the biological and
pathological roles of different RNA modifications. The RNA methyltransferase METTL1 …

[HTML][HTML] Codon-based indices for modeling gene expression and transcript evolution

S Bahiri-Elitzur, T Tuller - Computational and Structural Biotechnology …, 2021 - Elsevier
Codon usage bias (CUB) refers to the phenomena that synonymous codons are used in
different frequencies in most genes and organisms. The general assumption is that codon …

System-wide analysis of RNA and protein subcellular localization dynamics

E Villanueva, T Smith, M Pizzinga, M Elzek… - Nature …, 2024 - nature.com
Although the subcellular dynamics of RNA and proteins are key determinants of cell
homeostasis, their characterization is still challenging. Here we present an integrative …

High CO2 levels drive the TCA cycle backwards towards autotrophy

L Steffens, E Pettinato, TM Steiner, A Mall, S König… - Nature, 2021 - nature.com
It has recently been shown that in anaerobic microorganisms the tricarboxylic acid (TCA)
cycle, including the seemingly irreversible citrate synthase reaction, can be reversed and …

Estimating maximal microbial growth rates from cultures, metagenomes, and single cells via codon usage patterns

JL Weissman, S Hou… - Proceedings of the …, 2021 - National Acad Sciences
Maximal growth rate is a basic parameter of microbial lifestyle that varies over several orders
of magnitude, with doubling times ranging from a matter of minutes to multiple days. Growth …

A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity

C Kimchi-Sarfaty, JM Oh, IW Kim, ZE Sauna… - Science, 2007 - science.org
Synonymous single-nucleotide polymorphisms (SNPs) do not produce altered coding
sequences, and therefore they are not expected to change the function of the protein in …

The code of silence: widespread associations between synonymous codon biases and gene function

F Supek - Journal of molecular evolution, 2016 - Springer
Some mutations in gene coding regions exchange one synonymous codon for another, and
thus do not alter the amino acid sequence of the encoded protein. Even though they are …

Comparative analysis of codon bias in the chloroplast genomes of theaceae species

Z Wang, Q Cai, Y Wang, M Li, C Wang, Z Wang… - Frontiers in …, 2022 - frontiersin.org
Theaceae species are dicotyledonous angiosperms with extremely high ornamental and
economic value. The chloroplast genome is traditionally used to study species evolution …