Application of PLGA as a biodegradable and biocompatible polymer for pulmonary delivery of drugs

R Mahar, A Chakraborty, N Nainwal, R Bahuguna… - Aaps Pharmscitech, 2023 - Springer
Pulmonary administration of biodegradable polymeric formulation is beneficial in the
treatment of various respiratory diseases. For respiratory delivery, the polymer must be non …

Opportunistic etiological agents causing lung infections: emerging need to transform lung-targeted delivery

SK Debnath, M Debnath, R Srivastava - Heliyon, 2022 - cell.com
Lung diseases continue to draw considerable attention from biomedical and public health
care agencies. The lung with the largest epithelial surface area is continuously exposed to …

Development and evaluation of Chitosan nanoparticles based dry powder inhalation formulations of Prothionamide

SK Debnath, S Saisivam, M Debanth, A Omri - PloS one, 2018 - journals.plos.org
Prothionamide (PTH), a second line antitubercular drug is used to administer in
conventional oral route. However, its unpredictable absorption and frequent administration …

Dry powder inhalers of antitubercular drugs

N Nainwal, Y Sharma, V Jakhmola - Tuberculosis, 2022 - Elsevier
Despite advancements in the medical and pharmaceutical fields, tuberculosis remains a
major health problem globally. Patients do not widely accept the conventional approach to …

Targeted delivery of ursolic acid and oleanolic acid to lungs in the form of an inhaler for the management of tuberculosis: pharmacokinetic and toxicity assessment

V Saini, SK Debnath, P Maske, V Dighe, R Srivastava - PLoS One, 2022 - journals.plos.org
Introduction Ursolic acid (UA) and oleanolic acid (OA) are triterpenoids. They are used to
treat numerous diseases, including tuberculosis. Combinations of these drugs provide new …

Selective drug deposition in lungs through pulmonary drug delivery system for effective management of drug-resistant TB

K Sankhe, T Khan, C Bhavsar, M Momin… - Expert opinion on drug …, 2019 - Taylor & Francis
Introduction: The emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively
drug-resistant tuberculosis (XDR-TB) is a major health issue and continues to be a global …

Aerosolizable pyrazinamide-loaded biodegradable nanoparticles for the management of pulmonary tuberculosis

K Parmar, S Sondarva - Journal of Aerosol Medicine and Pulmonary …, 2024 - liebertpub.com
Background: Pyrazinamide is a Biopharmaceutical Classification System class III antibiotic
indicated for active tuberculosis. Methods: In the present work, pyrazinamide-loaded …

Status of inhalable antimicrobial agents for lung infection: progress and prospects

SK Debnath, R Srivastava, M Debnath… - Expert Review of …, 2021 - Taylor & Francis
Introduction: Available parenteral and oral administration of antimicrobial agents (AMAs) in
respiratory infections often show less penetration into the lung parenchyma. Due to …

Prospects of Inhalable Formulations of Conventionally Administered Repurposed Drugs for Adjunctive Treatment of Drug-Resistant Tuberculosis: Supporting …

R Ranjan, VSR Devireddy - Journal of Aerosol Medicine and …, 2024 - liebertpub.com
Background: Drug resistant tuberculosis is a major public health concern, since the
causative agent Mycobacterium tuberculosis is resistant to the most effective drugs against …

Creationa and Assessment of Dry Powder Inhalation Formulations of Gamma Oryzanol Based on Chitosan Nanoparticles.

VK Patel - Journal of Advanced Zoology, 2023 - search.ebscohost.com
Gamma oryzanol is an antioxidant and anticancer medication that is taken orally by a
traditional method. It comes from plants. Its utility is nonetheless restricted by its erratic …