Micropatterning the organization of multicellular structures in 3D biological hydrogels; insights into collective cellular mechanical interactions

B Ergaz, S Goren, A Lesman - Biofabrication, 2023 - iopscience.iop.org
Control over the organization of cells at the microscale level within supporting biomaterials
can push forward the construction of complex tissue architectures for tissue engineering …

Strain gradient programming in 3D fibrous hydrogels to direct graded cell alignment

A Kolel, B Ergaz, S Goren, O Tchaicheeyan… - Small …, 2023 - Wiley Online Library
Biological tissues experience various stretch gradients which act as mechanical signaling
from the extracellular environment to cells. These mechanical stimuli are sensed by cells …

Micro-tensile rheology of fibrous gels quantifies strain-dependent anisotropy

S Goren, B Ergaz, D Barak, R Sorkin, A Lesman - Acta Biomaterialia, 2024 - Elsevier
Semiflexible fiber gels such as collagen and fibrin have unique nonlinear mechanical
properties that play an important role in tissue morphogenesis, wound healing, and cancer …

Probing local force propagation in tensed fibrous gels

S Goren, M Levin, G Brand, A Lesman, R Sorkin - Small, 2023 - Wiley Online Library
Fibrous hydrogels are a key component of soft animal tissues. They support cellular
functions and facilitate efficient mechanical communication between cells. Due to their …

Measuring full-field strain of the muscle-tendon junction using confocal microscopy combined with digital volume correlation

N Iwasaki, B Morrison, A Karali, M Roldo… - Journal of the mechanical …, 2025 - Elsevier
The muscle-tendon junction (MTJ) is a specialised interface that facilitates the transmission
of force from the muscle to the tendon which has been implicated in muscle strains and …

Motion magnification analysis of microscopy videos of biological cells

O Shabi, S Natan, A Kolel, A Mukherjee… - Plos one, 2020 - journals.plos.org
It is well recognized that isolated cardiac muscle cells beat in a periodic manner. Recently,
evidence indicates that other, non-muscle cells, also perform periodic motions that are either …

FITC-dextran release from cell-embedded fibrin hydrogels

VR Lepsky, S Natan, O Tchaicheeyan, A Kolel… - Biomolecules, 2021 - mdpi.com
Fibrin hydrogel is a central biological material in tissue engineering and drug delivery
applications. As such, fibrin is typically combined with cells and biomolecules targeted to the …

Controlled strain of 3D hydrogels under live microscopy imaging

A Kolel, AR Riba, S Natan, O Tchaicheeyan… - Journal of Visualized …, 2020 - app.jove.com
External forces are an important factor in tissue formation, development, and maintenance.
The effects of these forces are often studied using specialized in vitro stretching methods …

[PDF][PDF] FITC-Dextran Release from Cell-Embedded Fibrin Hydrogels. Biomolecules 2021, 11, 337

VR Lepsky, S Natan, O Tchaicheeyan, A Kolel… - 2021 - academia.edu
Fibrin hydrogel is a central biological material in tissue engineering and drug delivery
applications. As such, fibrin is typically combined with cells and biomolecules targeted to the …