Mechanical properties of whole-body soft human tissues: a review

G Singh, A Chanda - Biomedical Materials, 2021 - iopscience.iop.org
The mechanical properties of soft tissues play a key role in studying human injuries and their
mitigation strategies. While such properties are indispensable for computational modelling …

Brain aging mechanisms with mechanical manifestations

Y Blinkouskaya, A Caçoilo, T Gollamudi… - Mechanisms of ageing …, 2021 - Elsevier
Brain aging is a complex process that affects everything from the subcellular to the organ
level, begins early in life, and accelerates with age. Morphologically, brain aging is primarily …

Moving beyond the glial scar for spinal cord repair

EJ Bradbury, ER Burnside - Nature communications, 2019 - nature.com
Traumatic spinal cord injury results in severe and irreversible loss of function. The injury
triggers a complex cascade of inflammatory and pathological processes, culminating in …

Fifty shades of brain: a review on the mechanical testing and modeling of brain tissue

S Budday, TC Ovaert, GA Holzapfel… - … Methods in Engineering, 2020 - Springer
Brain tissue is not only one of the most important but also the most complex and compliant
tissue in the human body. While long underestimated, increasing evidence confirms that …

[HTML][HTML] Mechanics in the nervous system: from development to disease

EK Pillai, K Franze - Neuron, 2024 - cell.com
Physical forces are ubiquitous in biological processes across scales and diverse contexts.
This review highlights the significance of mechanical forces in nervous system development …

Mechanical characterization of human brain tissue

S Budday, G Sommer, C Birkl, C Langkammer… - Acta biomaterialia, 2017 - Elsevier
Mechanics are increasingly recognized to play an important role in modulating brain form
and function. Computational simulations are a powerful tool to predict the mechanical …

Mechanosensing is critical for axon growth in the develo** brain

DE Koser, AJ Thompson, SK Foster, A Dwivedy… - Nature …, 2016 - nature.com
During nervous system development, neurons extend axons along well-defined pathways.
The current understanding of axon pathfinding is based mainly on chemical signaling …

The soft mechanical signature of glial scars in the central nervous system

E Moeendarbary, IP Weber, GK Sheridan… - Nature …, 2017 - nature.com
Injury to the central nervous system (CNS) alters the molecular and cellular composition of
neural tissue and leads to glial scarring, which inhibits the regrowth of damaged axons …

Automated model discovery for human brain using constitutive artificial neural networks

K Linka, SRS Pierre, E Kuhl - Acta Biomaterialia, 2023 - Elsevier
The brain is our softest and most vulnerable organ, and understanding its physics is a
challenging but significant task. Throughout the past decade, numerous competing models …

All roads lead to directional cell migration

A Shellard, R Mayor - Trends in cell biology, 2020 - cell.com
Directional cell migration normally relies on a variety of external signals, such as chemical,
mechanical, or electrical, which instruct cells in which direction to move. Many of the major …