Vascularization has a pivotal role in engineering successful tissue constructs. However, it
remains a major hurdle of bone tissue engineering, especially in clinical applications for the …

Xenotransplantation of patient-derived samples in mouse models has been instrumental in
depicting the role of hematopoietic stem and progenitor cells in the establishment as well as …

Polymer microcarriers are being extensively explored as cell delivery vehicles in cell-based
therapies and hybrid tissue and organ engineering. Spherical microcarriers are of particular …

Interconnected porosity is critical to the design of regenerative scaffolds, as it permits cell
migration, vascularisation and diffusion of nutrients and regulatory molecules inside the …

Craniofacial bones, separate from the appendicular skeleton, bear a significant amount of
strain and stress generated from mastication-related muscles. Current research on the …

Cancer cell lines have contributed immensely in understanding the complex physiology of
cancers. They are excellent material for studies as they offer homogenous samples without …

The production of veritable in-vitro models of bone tissue is essential to understand the
biology of bone and its surrounding environment, to analyze the pathogenesis of bone …

A major impediment to the development of therapies with mesenchymal stem
cells/multipotent stromal cells (MSC) is the poor survival and engraftment of MSCs at the site …

The generation of engineered models of the osteochondral complex to study its pathologies
and develop possible treatments is hindered by the distinctly different properties of articular …

A new concept of semipermeable reservoirs containing co-cultures of cells and supporting
microparticles is presented, inspired by the multi-phenotypic cellular environment of bone …