Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

The members of the Management and Therapy Subcommittee undertook an evidence-
based review of current dry eye therapies and management options. Management options …

Chronic liver disease when accompanied by underlying fibrosis, is characterized by an
accumulation of extracellular matrix (ECM) proteins and chronic inflammation. Although …

PRG4 is an extracellular matrix protein that maintains homeostasis through its boundary
lubricating and anti-inflammatory properties. Altered expression and function of PRG4 have …

During the osteoarthritis (OA) process, activation of immune systems, whether innate or
adaptive, is strongly associated with low-grade systemic inflammation. This process is …

Osteoarthritis (OA) is a degenerative joint disease involving both cartilage and synovium.
The canonical Wnt/β-catenin pathway, which is activated in OA, is emerging as an important …

Healthy synovial tissue includes a lining layer of synovial fibroblasts and macrophages. The
influx of leucocytes during active rheumatoid arthritis (RA) includes monocytes that …

The inflamed rheumatic joint is a highly heterogeneous and complex tissue with dynamic
recruitment and expansion of multiple cell types that interact in multifaceted ways within a …

Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis. In …

It is evident that components of the extracellular matrix (ECM) act as danger-associated
molecular patterns (DAMPs) through direct interactions with pattern recognition receptors …