It has become clear that the role of centrosomes extends well beyond that of important
microtubule organizers. There is increasing evidence that they also function as coordination …

Microtubule nucleation is regulated by the γ-tubulin ring complex (γTuRC) and related γ-
tubulin complexes, providing spatial and temporal control over the initiation of microtubule …

Microtubule (MT) filaments, composed of α/β-tubulin dimers, are fundamental to cellular
architecture, function and organismal development. They are nucleated from MT organizing …

Microtubules are composed of α-tubulin and β-tubulin dimers positioned head-to-tail to form
protofilaments that associate laterally in varying numbers. It is not known how cellular …

The microtubules that comprise mitotic spindles in animal cells are nucleated at
centrosomes and by spindle assembly factors that are activated in the vicinity of chromatin …

The γ-tubulin ring complex (γ-TuRC) is a structural template for de novo microtubule
assembly from α/β-tubulin units. The isolated vertebrate γ-TuRC assumes an asymmetric …

Life depends on cell proliferation and the accurate segregation of chromosomes, which are
mediated by the microtubule (MT)-based mitotic spindle and∼ 200 essential MT-associated …

Microtubules are essential for intracellular organization and chromosome segregation. They
are nucleated by the γ-tubulin ring complex (γTuRC). However, isolated vertebrate γTuRC …

Microtubules are cytoskeletal filaments central to a wide range of essential cellular functions
in eukaryotic cells. Consequently, cells need to exert tight control over when, where and how …

The γ-tubulin ring complex (γTuRC) is the major microtubule nucleator in cells. The
mechanism of its regulation is not understood. We purified human γTuRC and measured its …