A reduction in particle size improves the solubility and bioavailability of pharmaceuticals.
The traditional methods utilized in this regard are associated with problems so the use of …

Poor bioavailability and aqueous solubility represent a major constraint during the
development of new API molecules and can influence the impact of new medicines or halt …

Glibenclamide is an antidiabetic drug that also acts as an anti-inflammatory factor and
reduces oxidative stress, medullary edema, and heart attack. Glibenclamide has high …

The inability of many biopharmaceutical formulations to retain their structure and integrity
when in solution represents a major issue for their transport and storage, reducing their shelf …

This review was devoted to the technology and approach for improving nanosuspensions
stability in drug delivery to retrieve the state-of-the-art nanosuspensions. The main content of …

Abstract Posaconazole (PSZ), an anti-fungal drug, has broad-spectrum activity. But its action
is limited due to the poor solubility of posaconazole. The objective of the present study was …

The novel particle generation processes of Active Pharmaceutical Ingredient (API)/drug
have been extensively explored in recent decades due to their wide-range applications in …

Arbidol is a pharmaceutical compound of significant importance due to its versatile
applications in antiviral and Immunomodulatory therapies. The present study reports on the …

The low aqueous solubility and subsequently slow dissolution rate, as well as the poor
bioavailability of several active pharmaceutical ingredients (APIs), are major challenges in …

Gas antisolvent (GAS) processing, based on supercritical CO 2, was firstly explored to obtain
cocrystals of quercetin/L-proline (QUE/PRO). Cocrystallization is a novel mode to enhance …