Thyroid cancer is the fifth most common cancer in women in the USA, and an estimated over
62 000 new cases occurred in men and women in 2015. The incidence continues to rise …

Hepatocellular carcinoma (HCC) metabolism is redirected to glycolysis to enhance the
production of metabolic compounds employed by cancer cells to produce proteins, lipids …

Despite numerous screening tools for colorectal cancer (CRC), 25% of patients are
diagnosed with advanced disease. Novel diagnostic technologies that are early, accurate …

Colorectal cancer (CRC) is a heterogeneous disease with multiple underlying causative
genetic mutations. Genetic mutations in the phosphatidylinositol-3 kinase (PI3K) and the …

Background This phase I, four-arm, open-label study (NCT01347866) evaluated the
PI3K/mTOR inhibitors PF-04691502 (arms A, B) and gedatolisib (PF-05212384; arms C, D) …

Colorectal cancer (CRC) represents a significant global health burden, with high incidence
and mortality rates worldwide. Recent progress in research highlights the distinct clinical …

Background AZD0156 is an oral inhibitor of ATM, a serine threonine kinase that plays a key
role in DNA damage response (DDR) associated with double-strand breaks. Topoisomerase …

Advanced stages of papillary and anaplastic thyroid cancer continue to be plagued by a
dismal prognosis, which is a result of limited effective therapies for these cancers. Due to the …

Diffuse intrinsic pontine glioma (DIPG) is a devastating disease with an extremely poor
prognosis. Recent studies have shown that platelet-derived growth factor receptor (PDGFR) …

Polypharmacology has been increasingly advocated for the therapeutic intervention in
complex pathological conditions, exemplified by cancer. Although kinase inhibitors (KIs) …