Mechanisms of fibrosis: therapeutic translation for fibrotic disease
TA Wynn, TR Ramalingam - Nature medicine, 2012 - nature.com
Fibrosis is a pathological feature of most chronic inflammatory diseases. Fibrosis, or
scarring, is defined by the accumulation of excess extracellular matrix components. If highly …
scarring, is defined by the accumulation of excess extracellular matrix components. If highly …
Host responses in tissue repair and fibrosis
JS Duffield, M Lupher, VJ Thannickal… - Annual Review of …, 2013 - annualreviews.org
Myofibroblasts accumulate in the spaces between organ structures and produce
extracellular matrix (ECM) proteins, including collagen I. They are the primary “effector” cells …
extracellular matrix (ECM) proteins, including collagen I. They are the primary “effector” cells …
Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice
F Meng, K Wang, T Aoyama, SI Grivennikov, YH Paik… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: Interleukin (IL)-17 signaling has been implicated in lung and skin
fibrosis. We examined the role of IL-17 signaling in the pathogenesis of liver fibrosis in mice …
fibrosis. We examined the role of IL-17 signaling in the pathogenesis of liver fibrosis in mice …
Mechanisms of rejection: current perspectives
KJ Wood, R Goto - Transplantation, 2012 - journals.lww.com
Rejection is the major barrier to successful transplantation. The immune response to an
allograft is an ongoing dialogue between the innate and adaptive immune system that if left …
allograft is an ongoing dialogue between the innate and adaptive immune system that if left …
Deciphering the role of Th17 cells in human disease
Since their identification in 2005, T helper (Th) 17 cells have been proposed to play
important roles in several human diseases, including various autoimmune conditions …
important roles in several human diseases, including various autoimmune conditions …
Immune mechanisms in fibrotic pulmonary sarcoidosis
Sarcoidosis is an immune-mediated disorder. Its immunopathology has been steadily
mapped out over the past few decades. Despite this, the underpinning mechanisms for …
mapped out over the past few decades. Despite this, the underpinning mechanisms for …
CD4+ T‐cell subsets in transplantation
Z Liu, H Fan, S Jiang - Immunological reviews, 2013 - Wiley Online Library
The identification of T‐helper 9 (Th9), Th17, Th22 cells as distinct subsets of CD 4+ T cells
has extended the Th1/Th2 paradigm in the adaptive immunity. In the past decade, many …
has extended the Th1/Th2 paradigm in the adaptive immunity. In the past decade, many …
The Th17 pathway in vascular inflammation: culprit or consort?
M Robert, P Miossec, A Hot - Frontiers in Immunology, 2022 - frontiersin.org
The involvement of IL-17A in autoimmune and inflammatory diseases has prompted the
development of therapeutic strategies to block the Th17 pathway. Promising results came …
development of therapeutic strategies to block the Th17 pathway. Promising results came …
Interleukin-6 in renal disease and therapy
Abstract Interleukin (IL)-6 has become a major target for clinical intervention in various
autoimmune conditions. Here, drugs including the humanized anti-IL-6 receptor (IL-6R) …
autoimmune conditions. Here, drugs including the humanized anti-IL-6 receptor (IL-6R) …
TGF‐β‐secreting regulatory B cells: unsung players in immune regulation
G Huai, JF Markmann, S Deng… - Clinical & Translational …, 2021 - Wiley Online Library
Regulatory B cells contribute to the regulation of immune responses in cancer, autoimmune
disorders, allergic conditions and inflammatory diseases. Although most studies focus on …
disorders, allergic conditions and inflammatory diseases. Although most studies focus on …