Autophagy is a process that targets various intracellular elements for degradation.
Autophagy can be non-selective—associated with the indiscriminate engulfment of cytosolic …

Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They
have a unique architecture consisting of a hydrophobic core of neutral lipids, which is …

Compartmentalization is a defining characteristic of eukaryotic cells, and partitions distinct
biochemical processes into discrete subcellular locations. Microscopy and biochemical …

Ferroptosis is a form of regulated cell death that is caused by the iron-dependent
peroxidation of lipids,. The glutathione-dependent lipid hydroperoxidase glutathione …

INTRODUCTION In all eukaryotic cells, lipid droplets (LDs) store and supply essential lipids
to produce signaling molecules, membrane building blocks, and metabolic energy. The LD …

Dietary mono-unsaturated fatty acids (MUFAs) are linked to longevity in several species. But
the mechanisms by which MUFAs extend lifespan remain unclear. Here we show that an …

We introduce APEX-seq, a method for RNA sequencing based on direct proximity labeling of
RNA using the peroxidase enzyme APEX2. APEX-seq in nine distinct subcellular locales …

In addition to tau and Aβ pathologies, inflammation plays an important role in Alzheimer's
disease (AD). Variants in APOE and TREM2 increase AD risk. ApoE4 exacerbates tau …

Background Non-alcoholic fatty liver disease (NAFLD) is defined by the abundance of lipid
droplets (LDs) in hepatocytes. While historically considered simply a depot for energy …

Many disease pathologies can be understood through the elucidation of localized
biomolecular networks, or microenvironments. To this end, enzymatic proximity labeling …