Despite clinical and scientific advancements, heart failure is the major cause of morbidity
and mortality worldwide. Both mitochondrial dysfunction and inflammation contribute to the …

Purpose of Review Mitochondria are recognized to be one of the most important organelles
in chondrocytes for their role in triphosphate (ATP) generation through aerobic …

Tendinopathy is a prevalent aging-related disorder characterized by pain, swelling, and
impaired function, often resulting from micro-scarring and degeneration caused by overuse …

Chronic inflammatory musculoskeletal disorders characterized by prolonged muscle
inflammation, resulting in enduring pain and diminished functionality, pose significant …

Cells' structure is key to understanding cellular function, diagnostics, and therapy
development. Soft X-ray tomography (SXT) is a unique tool to image cellular structure …

The skeletal muscle is one of the largest organs in the mammalian body. Its remarkable
ability to swiftly shift its substrate selection allows other organs like the brain to choose their …

Mitochondria receive cholesterol from late endosomes and lysosomes (LE/LYSs) or from the
plasma membrane for production of oxysterols and steroid hormones. This process depends …

An extensive review is presented on mitochondrial structure and function, mitochondrial
proteins, the outer and inner membranes, cristae, the role of F1FO-ATP synthase, the …

Methodological developments in biomedical research are currently moving towards single-
cell approaches. This allows for a much better spatial and functional characterization of, for …

Background Mitochondria are cellular organelles responsible for energy production, and
dysregulation of the mitochondrial network is associated with many disease states. To fully …