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A genetically encoded, phage‐displayed cyclic‐peptide library
Superior to linear peptides in biological activities, cyclic peptides are considered to have
great potential as therapeutic agents. To identify cyclic‐peptide ligands for therapeutic …
great potential as therapeutic agents. To identify cyclic‐peptide ligands for therapeutic …
MaveDB: an open-source platform to distribute and interpret data from multiplexed assays of variant effect
Multiplex assays of variant effect (MAVEs), such as deep mutational scans and massively
parallel reporter assays, test thousands of sequence variants in a single experiment. Despite …
parallel reporter assays, test thousands of sequence variants in a single experiment. Despite …
Molecular evolution of peptides by yeast surface display technology
Genetically encoded peptides possess unique properties, such as a small molecular weight
and ease of synthesis and modification, that make them suitable to a large variety of …
and ease of synthesis and modification, that make them suitable to a large variety of …
Deep learning-based bioactive therapeutic peptide generation and screening
Many bioactive peptides demonstrated therapeutic effects over complicated diseases, such
as antiviral, antibacterial, anticancer, etc. It is possible to generate a large number of …
as antiviral, antibacterial, anticancer, etc. It is possible to generate a large number of …
Nonproteinogenic deep mutational scanning of linear and cyclic peptides
High-resolution structure–activity analysis of polypeptides requires amino acid structures
that are not present in the universal genetic code. Examination of peptide and protein …
that are not present in the universal genetic code. Examination of peptide and protein …
Dual-color bioluminescent sensor proteins for therapeutic drug monitoring of antitumor antibodies
M van Rosmalen, Y Ni, DFM Vervoort, R Arts… - Analytical …, 2018 - ACS Publications
Monitoring the levels of therapeutic antibodies in individual patients would allow patient-
specific dose optimization, with the potential for major therapeutic and financial benefits. Our …
specific dose optimization, with the potential for major therapeutic and financial benefits. Our …
Ratiometric bioluminescent sensor proteins based on intramolecular split luciferase complementation
Bioluminescent sensor proteins provide attractive tools for applications ranging from in vivo
imaging to point-of-care testing. Here we introduce a new class of ratiometric bioluminescent …
imaging to point-of-care testing. Here we introduce a new class of ratiometric bioluminescent …
Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins
E Mihara, S Watanabe, NK Bashiruddin… - Nature …, 2021 - nature.com
Protein engineering has great potential for devising multifunctional recombinant proteins to
serve as next-generation protein therapeutics, but it often requires drastic modifications of …
serve as next-generation protein therapeutics, but it often requires drastic modifications of …
Protein Grafting Techniques: From Peptide Epitopes to Lasso‐Grafted Neobiologics
M Imai, K Colas, H Suga - ChemPlusChem, 2024 - Wiley Online Library
Protein engineering techniques have vastly expanded their domain of impact, notably
following the success of antibodies. Likewise, smaller peptide therapeutics have carved an …
following the success of antibodies. Likewise, smaller peptide therapeutics have carved an …
A platform to enhance quantitative single molecule localization microscopy
Quantitative single molecule localization microscopy (qSMLM) is a powerful approach to
study in situ protein organization. However, uncertainty regarding the photophysical …
study in situ protein organization. However, uncertainty regarding the photophysical …