Ribonucleotide reductase class I with different radical generating clusters
AB Tomter, G Zoppellaro, NH Andersen… - Coordination chemistry …, 2013 - Elsevier
Ribonucleotide reductase (RNR) catalyzes the rate limiting step in DNA synthesis where
ribonucleotides are reduced to their corresponding deoxyribonucleotides. They are formed …
ribonucleotides are reduced to their corresponding deoxyribonucleotides. They are formed …
New insights into controlling radical migration pathways in heme enzymes gained from the study of a dye-decolorising peroxidase
In heme enzymes, such as members of the dye-decolorising peroxidase (DyP) family, the
formation of the highly oxidising catalytic Fe (IV)-oxo intermediates following reaction with …
formation of the highly oxidising catalytic Fe (IV)-oxo intermediates following reaction with …
Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine β145
Abstract Aim: Hemoglobin (Hb) becomes toxic when released from the erythrocyte. The
acute phase protein haptoglobin (Hp) binds avidly to Hb and decreases oxidative damage to …
acute phase protein haptoglobin (Hp) binds avidly to Hb and decreases oxidative damage to …
The hydrogen-peroxide-induced radical behaviour in human cytochrome c–phospholipid complexes: implications for the enhanced pro-apoptotic activity of the G41S …
BS Rajagopal, AN Edzuma, MA Hough… - Biochemical …, 2013 - portlandpress.com
We have investigated whether the pro-apoptotic properties of the G41S mutant of human
cytochrome c can be explained by a higher than wild-type peroxidase activity triggered by …
cytochrome c can be explained by a higher than wild-type peroxidase activity triggered by …
Biophysical Characterization of Fluorotyrosine Probes Site-Specifically Incorporated into Enzymes: E. coli Ribonucleotide Reductase As an Example
Fluorinated tyrosines (F n Y's, n= 2 and 3) have been site-specifically incorporated into E.
coli class Ia ribonucleotide reductase (RNR) using the recently evolved M. jannaschii Y …
coli class Ia ribonucleotide reductase (RNR) using the recently evolved M. jannaschii Y …
Compound ES of dehaloperoxidase decays via two alternative pathways depending on the conformation of the distal histidine
MK Thompson, S Franzen, RA Ghiladi… - Journal of the …, 2010 - ACS Publications
Dehaloperoxidase (DHP) is a respiratory hemoglobin (Hb) that has been shown to catalyze
the conversion of trihalophenols to dihaloquinones in the presence of hydrogen peroxide …
the conversion of trihalophenols to dihaloquinones in the presence of hydrogen peroxide …
The toolbox of Auricularia auricula-judae dye-decolorizing peroxidase–Identification of three new potential substrate-interaction sites
E Strittmatter, K Serrer, C Liers, R Ullrich… - Archives of biochemistry …, 2015 - Elsevier
Dye-decolorizing peroxidases (DyPs) such as AauDyPI from the fungus Auricularia auricula-
judae are able to oxidize substrates of different kinds and sizes. A crystal structure of an …
judae are able to oxidize substrates of different kinds and sizes. A crystal structure of an …
Mechanism of diol dehydration by a promiscuous radical‐SAM enzyme homologue of the antiviral enzyme viperin (RSAD2)
K Honarmand Ebrahimi, JS Rowbotham… - …, 2020 - Wiley Online Library
Deoxynucleotides are an important class of drugs because they interfere with the
metabolism of nucleotides, and their incorporation into DNA or RNA terminates cell division …
metabolism of nucleotides, and their incorporation into DNA or RNA terminates cell division …
An aromatic dyad motif in dye decolourising peroxidases has implications for free radical formation and catalysis
AK Chaplin, TM Chicano, BV Hampshire… - … A European Journal, 2019 - Wiley Online Library
Dye decolouring peroxidases (DyPs) are the most recent class of heme peroxidase to be
discovered. On reacting with H2O2, DyPs form a high‐valent iron (IV)‐oxo species and a …
discovered. On reacting with H2O2, DyPs form a high‐valent iron (IV)‐oxo species and a …
Spectroscopic comparison of photogenerated tryptophan radicals in azurin: effects of local environment and structure
HS Shafaat, BS Leigh, MJ Tauber… - Journal of the American …, 2010 - ACS Publications
Tryptophan radicals play a significant role in mediating biological electron transfer. We
report the photogeneration of a long-lived, neutral tryptophan radical (Az48W•) from the …
report the photogeneration of a long-lived, neutral tryptophan radical (Az48W•) from the …