In this work, we constructed a Collagen I–Matrigel composite extracellular matrix (ECM). The
composite ECM was used to determine the influence of the local collagen fiber orientation …

Biophysical stimuli presented to cells via microenvironmental properties (eg, alignment and
stiffness) or external forces have a significant impact on cell function and behavior. Recently …

Pathogenic mutations in LAMIN A/C (LMNA) cause abnormal nuclear structure and
laminopathies. These diseases have myriad tissue-specific phenotypes, including dilated …

Current limitations in cardiac tissue engineering revolve around the inability to fully
recapitulate the structural organization and mechanical environment of native cardiac tissue …

The posterior face of the cornea consists of the corneal endothelium, a monolayer of
cuboidal cells that secrete and attach to Descemet's membrane, an exaggerated basement …

Since the last 10 years, AFM has become a powerful tool to study biological samples.
However, the classical modes offered (imaging or tap** mode) often damage sample that …

Purpose: Treatment with corticosteroids can result in ocular hypertension and may lead to
the development of steroid-induced glaucoma. The extent to which biomechanical changes …

Cells are able to perceive complex mechanical cues from their microenvironment, which in
turn influences their development. Although the understanding of these intricate …

Dysmorphic nuclei are commonly seen in cancers and provide strong motivation for studying
in various cancer contexts the main structural proteins of nuclei, the lamins. Past studies …

Although nanotopography has been shown to be a potent modulator of cell behavior, it is
unclear how the nanotopographical cue, through focal adhesions, affects the nucleus …