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Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …
Ribosome biogenesis in disease: new players and therapeutic targets
L Jiao, Y Liu, XY Yu, X Pan, Y Zhang, J Tu… - Signal transduction and …, 2023 - nature.com
The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome
biogenesis is the process that generates ribosomes and plays an essential role in cell …
biogenesis is the process that generates ribosomes and plays an essential role in cell …
Role of RNA modifications in cancer
Specific chemical modifications of biological molecules are an efficient way of regulating
molecular function, and a plethora of downstream signalling pathways are influenced by the …
molecular function, and a plethora of downstream signalling pathways are influenced by the …
The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities
RNA modifications have recently emerged as critical posttranscriptional regulators of gene
expression programmes. Significant advances have been made in understanding the …
expression programmes. Significant advances have been made in understanding the …
RNA modification: mechanisms and therapeutic targets
RNA modifications are dynamic and reversible chemical modifications on substrate RNA
that are regulated by specific modifying enzymes. They play important roles in the regulation …
that are regulated by specific modifying enzymes. They play important roles in the regulation …
Tuning the ribosome: the influence of rRNA modification on eukaryotic ribosome biogenesis and function
ABSTRACT rRNAs are extensively modified during their transcription and subsequent
maturation in the nucleolus, nucleus and cytoplasm. RNA modifications, which are installed …
maturation in the nucleolus, nucleus and cytoplasm. RNA modifications, which are installed …
Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine
Cancer is one of the major diseases threatening human life and health worldwide.
Epigenetic modification refers to heritable changes in the genetic material without any …
Epigenetic modification refers to heritable changes in the genetic material without any …
Decoding pseudouridine: an emerging target for therapeutic development
Pseudouridine (Ψ) is the most abundant post-transcriptional RNA modification and is
widespread in multiple RNA species. Ψ impacts various aspects of RNA biology, conferring …
widespread in multiple RNA species. Ψ impacts various aspects of RNA biology, conferring …
RNA modification in cardiovascular disease: implications for therapeutic interventions
C Wang, X Hou, Q Guan, H Zhou, L Zhou… - Signal transduction and …, 2023 - nature.com
Cardiovascular disease (CVD) is the leading cause of death in the world, with a high
incidence and a youth-oriented tendency. RNA modification is ubiquitous and indispensable …
incidence and a youth-oriented tendency. RNA modification is ubiquitous and indispensable …
New frontiers in translational control of the cancer genome
The past several years have seen dramatic leaps in our understanding of how gene
expression is rewired at the translation level during tumorigenesis to support the …
expression is rewired at the translation level during tumorigenesis to support the …