Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …

Constitutive activation of the Hedgehog (Hh) signaling pathway is associated with increased
risk of develo** several malignancies. The biological and pathogenic importance of Hh …

Cancer-associated fibroblasts (CAFs) play critical roles in cancer progression and treatment
failure. CAFs display extreme phenotypic heterogeneity and functional diversity. Some …

A library of new phenstatin based indole linked chalcone compounds (9a-z and 9aa-ad)
were designed and synthesized. Of these, compound 9a with 1-methyl, 2-and 3-methoxy …

Introduction Medulloblastoma (MB) is a heterogeneous tumor of the cerebellum that is
divided into four main subgroups with distinct molecular and clinical features. Sonic …

Hedgehog, a developmental morphogen, and its downstream signalling have recently been
associated with metabolic control. Sonic hedgehog signalling (Shh) is a significant pathway …

Aberrant activation of hedgehog (Hh) signaling has been observed in a wide variety of
tumors and accounts for more than 25% of human cancer deaths. Inhibitors targeting the Hh …

WNT-Frizzled (FZD) signaling plays a critical role in embryonic development, stem cell
regulation and tissue homeostasis. FZDs are linked to severe human pathology and are …

Several natural products have been suggested as effective agents for the treatment of
cancer. Given the important role of CSCs (Cancer Stem Cells) in cancer, which is a trendy …

The development of local recurrence and metastatic disease, most probably attributable to
the intrinsic or acquired resistance of tumor cells to standard therapy, still constitute the …