The sequence of heterocyclic bases on the interior of the DNA double helix constitutes the
genetic code that drives the operation of all living organisms. With this said, it is not …

Search for the formation of oxidatively base damage in cellular DNA has been a matter of
debate for more than 40years due to the lack of accurate methods for the measurement of …

A variety of endogenous and exogenous agents can induce DNA damage and lead to
genomic instability. Reactive oxygen species (ROS), an important class of DNA damaging …

Hydroxyl radical (radical dot OH) and one-electron oxidants that may be endogenously
formed through oxidative metabolism, phagocytosis, inflammation and pathological …

Purpose: The aim of this survey is to critically review the available information on one-
electron oxidation reactions of nucleobases in cellular DNA with emphasis on damage …

The quick progress of epigenetic study has kindled new hope for treating many cancers.
When it comes to RNA epigenetics, the ac4C acetylation modification is showing promise …

Inert CrH bond functionalization is usually performed by dioxygen-utilizing enzymes through
the insertion of an oxygen atom into the CrH bond. Alternative reactions include …

The UV components of sunlight (UVA and UVB) are implicated in the etiology of human skin
cancer. The underlying mechanism of action for UVB carcinogenicity is well defined; …

The integrity of the human genome is frequently challenged by endogenous and exogenous
agents, and reactive oxygen species (ROS) constitute the major endogenous source of DNA …

It is a commonly held view that oxidatively induced DNA lesions are repaired by the base
excision repair (BER) pathway, whereas DNA lesions induced by UV light and other “bulky” …