CNS tumors remain among the deadliest forms of cancer, resisting conventional and new
treatment approaches, with mortality rates staying practically unchanged over the past 30 …

Highlights•Existing models for drug discovery and development against glioblastoma
multiforme (GBM) have limitations.•We review advances in 3D systems that promise more …

Background Glial scar formation is a reactive glial response confining injured regions in a
central nervous system. However, it remains challenging to identify key factors formulating …

Simple Summary Glioblastoma is the most lethal primary adult brain tumor. The great
number of mutations involved and the aggressiveness of glioblastoma render this type of …

Introduction: The blood-brain barrier (BBB) selectively impedes the transportation of drug
molecules into the brain, which makes the drug delivery and targeting of brain tumors very …

High‐grade gliomas are the most common and most malign primary brain tumors. Current
therapy approaches only reach unsatisfactory results, still not providing a long‐lasting time …

Glioblastoma (GBM) is the most common and malignant type of primary brain tumor. Even
after surgery and chemoradiotherapy, residual GBM cells can infiltrate the healthy brain …

Glioblastoma (GBM) is a poorly treatable disease due to the fast development of tumor
recurrences and high resistance to chemo-and radiotherapy. To overcome the highly …

Current treatment strategies for glioblastoma (GBM) including surgical resection and
adjuvant radio/chemotherapy result in a limited progression-free survival time of patients …

Glioblastomas (GBMs) are characterized by high heterogeneity, involving diverse cell types,
including those with stem‐like features contributing to GBM's malignancy. Moreover …