Divergent gold catalysis: unlocking molecular diversity through catalyst control
The catalyst-directed divergent synthesis, commonly termed as “divergent catalysis”, has
emerged as a promising technique as it allows chartering of structurally distinct products …
emerged as a promising technique as it allows chartering of structurally distinct products …
Optimization of catalysts and conditions in gold (I) catalysis—counterion and additive effects
Gold catalysis has proven to be an important breakthrough for organic synthesis. The
tunable nature of gold catalysts, the unique properties of gold, and the mild reaction …
tunable nature of gold catalysts, the unique properties of gold, and the mild reaction …
Sequential and direct multicomponent reaction (MCR)-based dearomatization strategies
Dearomatization strategies in a multicomponent fashion often result in complex heterocyclic
frameworks, which have attracted the attention of chemists due to their natural product-like …
frameworks, which have attracted the attention of chemists due to their natural product-like …
Recent advances in the asymmetric synthesis of pharmacology-relevant nitrogen heterocycles via stereoselective aza-Michael reactions
MG Vinogradov, OV Turova, SG Zlotin - Organic & Biomolecular …, 2019 - pubs.rsc.org
The prevalence of nitrogen containing heterocycles in natural products and pharmaceuticals
is a doubtless fact. In this review, recent applications of a stereoselective aza-Michael …
is a doubtless fact. In this review, recent applications of a stereoselective aza-Michael …
Recent advances in post Ugi-4CR dearomatizations for constructing spiro heterocycles
The Ugi reaction has obtained broad interest due to mild reaction conditions and high
variability. The versatile Ugi adducts provide myriad opportunities for post-transformations …
variability. The versatile Ugi adducts provide myriad opportunities for post-transformations …
Synthesis of trisubstituted hydroxylamines by a visible light-promoted multicomponent reaction
A green and efficient method for the synthesis of trisubstituted hydroxylamines from β-keto
ester, 2-nitrosopyridine and aryldiazoacetates has been developed. This multicomponent …
ester, 2-nitrosopyridine and aryldiazoacetates has been developed. This multicomponent …
A Gold‐Catalyzed Domino Cyclization Enabling Rapid Construction of Diverse Polyheterocyclic Frameworks
We report herein an efficient gold (I)‐catalyzed post‐Ugi domino dearomatization/ipso‐
cyclization/Michael sequence that enables access to libraries of diverse (hetero) arene …
cyclization/Michael sequence that enables access to libraries of diverse (hetero) arene …
Recent advances in the catalytic dearomatization of naphthols
J An, M Bandini - European Journal of Organic Chemistry, 2020 - Wiley Online Library
The catalytic dearomatization of naphthols offers a unique platform to rapidly access
structurally complex and densely functionalized molecular architectures. Thermodynamically …
structurally complex and densely functionalized molecular architectures. Thermodynamically …
Post-Ugi cyclization for the construction of diverse heterocyclic compounds: recent updates
Multicomponent reactions (MCRs) have proved as a valuable tool for organic and medicinal
chemist because of their ability to introduce a large degree of chemical diversity in the …
chemist because of their ability to introduce a large degree of chemical diversity in the …
Palladium-catalyzed arylative dearomatization and subsequent aromatization/dearomatization/aza-Michael addition: Access to Zephycarinatine and Zephygranditine …
We have developed a novel palladium-catalyzed arylative dearomatization and subsequent
aromatization/dearomatization/aza-Michael addition process of Ugi adducts, enabling the …
aromatization/dearomatization/aza-Michael addition process of Ugi adducts, enabling the …