Divergent gold catalysis: unlocking molecular diversity through catalyst control

CC Chintawar, AK Yadav, A Kumar… - Chemical …, 2021 - ACS Publications
The catalyst-directed divergent synthesis, commonly termed as “divergent catalysis”, has
emerged as a promising technique as it allows chartering of structurally distinct products …

Optimization of catalysts and conditions in gold (I) catalysis—counterion and additive effects

Z Lu, T Li, SR Mudshinge, B Xu… - Chemical …, 2021 - ACS Publications
Gold catalysis has proven to be an important breakthrough for organic synthesis. The
tunable nature of gold catalysts, the unique properties of gold, and the mild reaction …

Sequential and direct multicomponent reaction (MCR)-based dearomatization strategies

UK Sharma, P Ranjan, EV Van der Eycken… - Chemical Society …, 2020 - pubs.rsc.org
Dearomatization strategies in a multicomponent fashion often result in complex heterocyclic
frameworks, which have attracted the attention of chemists due to their natural product-like …

Recent advances in the asymmetric synthesis of pharmacology-relevant nitrogen heterocycles via stereoselective aza-Michael reactions

MG Vinogradov, OV Turova, SG Zlotin - Organic & Biomolecular …, 2019 - pubs.rsc.org
The prevalence of nitrogen containing heterocycles in natural products and pharmaceuticals
is a doubtless fact. In this review, recent applications of a stereoselective aza-Michael …

Recent advances in post Ugi-4CR dearomatizations for constructing spiro heterocycles

X Tang, Q Tao, L Song… - Organic Chemistry …, 2024 - pubs.rsc.org
The Ugi reaction has obtained broad interest due to mild reaction conditions and high
variability. The versatile Ugi adducts provide myriad opportunities for post-transformations …

Synthesis of trisubstituted hydroxylamines by a visible light-promoted multicomponent reaction

BG Cai, Q Li, Q Zhang, L Li, J Xuan - Organic Chemistry Frontiers, 2021 - pubs.rsc.org
A green and efficient method for the synthesis of trisubstituted hydroxylamines from β-keto
ester, 2-nitrosopyridine and aryldiazoacetates has been developed. This multicomponent …

A Gold‐Catalyzed Domino Cyclization Enabling Rapid Construction of Diverse Polyheterocyclic Frameworks

Y He, Z Li, K Robeyns, L Van Meervelt… - Angewandte Chemie …, 2018 - Wiley Online Library
We report herein an efficient gold (I)‐catalyzed post‐Ugi domino dearomatization/ipso‐
cyclization/Michael sequence that enables access to libraries of diverse (hetero) arene …

Recent advances in the catalytic dearomatization of naphthols

J An, M Bandini - European Journal of Organic Chemistry, 2020 - Wiley Online Library
The catalytic dearomatization of naphthols offers a unique platform to rapidly access
structurally complex and densely functionalized molecular architectures. Thermodynamically …

Post-Ugi cyclization for the construction of diverse heterocyclic compounds: recent updates

J Bariwal, R Kaur, LG Voskressensky… - Frontiers in …, 2018 - frontiersin.org
Multicomponent reactions (MCRs) have proved as a valuable tool for organic and medicinal
chemist because of their ability to introduce a large degree of chemical diversity in the …

Palladium-catalyzed arylative dearomatization and subsequent aromatization/dearomatization/aza-Michael addition: Access to Zephycarinatine and Zephygranditine …

C Liu, L Song, L Van Meervelt, VA Peshkov, Z Li… - Organic …, 2021 - ACS Publications
We have developed a novel palladium-catalyzed arylative dearomatization and subsequent
aromatization/dearomatization/aza-Michael addition process of Ugi adducts, enabling the …