A novel Phe‐206‐Leu mutation in acetolactate synthase confers resistance to penoxsulam in barnyardgrass (Echinochloa crus‐galli (L.) P. Beauv)

J Fang, D Yang, Z Zhao, J Chen… - Pest Management …, 2022 - Wiley Online Library
BACKGROUND Barnyardgrass (Echinochloa crus‐galli (L.) P. Beauv) has evolved
resistance to the acetolactate synthase (ALS) inhibitor penoxsulam which is used to control …

Structural basis of resistance to herbicides that target acetohydroxyacid synthase

T Lonhienne, Y Cheng, MD Garcia, SH Hu… - Nature …, 2022 - nature.com
Acetohydroxyacid synthase (AHAS) is the target for more than 50 commercial herbicides;
first applied to crops in the 1980s. Since then, 197 site-of-action resistance isolates have …

Structures of fungal and plant acetohydroxyacid synthases

T Lonhienne, YS Low, MD Garcia, T Croll, Y Gao… - Nature, 2020 - nature.com
Acetohydroxyacid synthase (AHAS), also known as acetolactate synthase, is a flavin
adenine dinucleotide-, thiamine diphosphate-and magnesium-dependent enzyme that …

A Novel AHAS-Inhibiting Herbicide Candidate for Controlling Leptochloa chinensis: A Devastating Weedy Grass in Rice Fields

Y Chen, Y Yan, J Chen, B Zheng, Y Jiang… - Journal of Agricultural …, 2024 - ACS Publications
Given the prevalence of the malignant weed Chinese Sprangletop (Leptochloa chinensis
(L.) Nees) in rice fields, the development of novel herbicides against this weed has aroused …

Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase

L **e, X Zang, W Cheng, Z Zhang, J Zhou… - Journal of the …, 2021 - ACS Publications
Acetohydroxyacid synthase (AHAS) is the first enzyme in the branched-chain amino acid
biosynthetic pathway and is a validated target for herbicide and fungicide development …

In search of herbistasis: COT-metsulfuron methyl displays rare herbistatic properties

H **ng, SKM McGregor, BD Batista, C Whitefield… - Chemical …, 2025 - pubs.rsc.org
Weed management is an essential intervention for maintaining food security and protecting
biodiversity but is heavily reliant on chemical control measures (ie, herbicides) …

Complete biosynthetic pathway of the phosphonate phosphonothrixin: two distinct thiamine diphosphate-dependent enzymes divide the work to form a C–C bond

Y Zhu, T Shiraishi, J Lin, K Inaba, A Ito… - Journal of the …, 2022 - ACS Publications
Phosphonates often exhibit biological activities by mimicking the phosphates and
carboxylates of biological molecules. The phosphonate phosphonothrixin (PTX), produced …

Genome-guided analysis of seven weed species reveals conserved sequence and structural features of key gene targets for herbicide development

S Shah, T Lonhienne, CE Murray, Y Chen… - Frontiers in Plant …, 2022 - frontiersin.org
Herbicides are commonly deployed as the front-line treatment to control infestations of
weeds in native ecosystems and among crop plants in agriculture. However, the prevalence …

Interactions between the ACT domains and catalytic subunits of acetohydroxyacid synthases (AHASs) from different species

Y **e, X Wen, D Zhao, C Niu, Y Zhao, H Qi… - ChemBioChem, 2018 - Wiley Online Library
Acetohydroxyacid synthase (AHAS), which catalyzes the first step in the biosynthesis of
branched‐chain amino acids, is a target of several types of potent herbicides and …

Synthetic Biology for Green Chemistry: Building In vivo Enzymatic Cascades Using Carboxylic Acid Reductases (CARs)

R Cutlan - 2022 - ore.exeter.ac.uk
Biocatalysis has a proven track record of offering replacements for individual chemical
reactions with a lower environmental impact. Cascade reactions are an extension of …