A decade of CDK5

R Dhavan, LH Tsai - Nature reviews Molecular cell biology, 2001 - nature.com
Since it was identified a decade ago, cyclin-dependent kinase 5 (CDK5) has emerged as a
crucial regulator of neuronal migration in the develo** central nervous system. CDK5 …

Cyclin-dependent kinases in brain development and disease

SC Su, LH Tsai - Annual review of cell and developmental …, 2011 - annualreviews.org
Cyclin-dependent kinase 5 (Cdk5) is a multifaceted serine/threonine kinase protein with
important roles in the nervous system. Two related proteins, p35 and p39, activate Cdk5 …

Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens

KW Lee, Y Kim, AM Kim, K Helmin, AC Nairn… - Proceedings of the …, 2006 - pnas.org
Psychostimulant-induced alteration of dendritic spines on dopaminoceptive neurons in
nucleus accumbens (NAcc) has been hypothesized as an adaptive neuronal response that …

Nuclear import impairment causes cytoplasmic trans-activation response DNA-binding protein accumulation and is associated with frontotemporal lobar degeneration

AL Nishimura, V Župunski, C Troakes, C Kathe… - Brain, 2010 - academic.oup.com
Trans-activation response DNA-binding protein (TDP-43) accumulation is the major
component of ubiquitinated protein inclusions found in patients with amyotrophic lateral …

Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration

Z **e, K Sanada, BA Samuels, H Shih, LH Tsai - Cell, 2003 - cell.com
The serine/threonine kinase Cdk5 plays an essential role in neuronal positioning during
corticogenesis, but the underlying mechanisms are unknown. In nonneuronal cells, the …

[HTML][HTML] Wnt/β-catenin signaling in dermal condensates is required for hair follicle formation

SY Tsai, R Sennett, A Rezza, C Clavel, L Grisanti… - Developmental …, 2014 - Elsevier
Broad dermal Wnt signaling is required for patterned induction of hair follicle placodes and
subsequent Wnt signaling in placode stem cells is essential for induction of dermal …

Transcriptional regulation of β-secretase by p25/cdk5 leads to enhanced amyloidogenic processing

Y Wen, WH Yu, B Maloney, J Bailey, J Ma, I Marié… - Neuron, 2008 - cell.com
Summary Cyclin-dependent kinase 5 (cdk5) has been implicated in Alzheimer's disease
(AD) pathogenesis. Here, we demonstrate that overexpression of p25, an activator of cdk5 …

Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the 'Dr. Jekyll and Mr. Hyde concept'of Alzheimer's disease or the yin and yang …

T Arendt - Progress in neurobiology, 2003 - Elsevier
Mental actions are based on the dynamic organization of neuronal networks. In particular,
phylogenetically young brain areas (eg, cortical associative circuits) involved in the …

Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells

CJ Strock, JI Park, EK Nakakura, GS Bova… - Cancer …, 2006 - aacrjournals.org
We show here that cyclin-dependent kinase 5 (CDK5), a known regulator of migration in
neuronal development, plays an important role in prostate cancer motility and metastasis …

Cables links Robo-bound Abl kinase to N-cadherin-bound β-catenin to mediate Slit-induced modulation of adhesion and transcription

J Rhee, T Buchan, L Zukerberg, J Lilien… - Nature cell biology, 2007 - nature.com
Binding of the secreted axon guidance cue Slit to its Robo receptor results in inactivation of
the neural, calcium-dependent cell–cell adhesion molecule N-cadherin, providing a rapid …