Background Inflammation in the lung is the body's natural response to injury. It acts to
remove harmful stimuli such as pathogens, irritants, and damaged cells and initiate the …

Introduction: Respiratory drug delivery is a surprisingly complex process with a number of
physical and biological challenges. Computational fluid dynamics (CFD) is a scientific …

Within a time span of only a few months, the SARS-CoV-2 virus has managed to spread
across the world. This virus can spread by close contact, which includes large droplet spray …

In 2010, a tissue‐engineered trachea was transplanted into a 10‐year‐old child using a
decellularized deceased donor trachea repopulated with the recipient's respiratory …

Prediction of the air-particle dynamics in human lungs can reveal critical deposition sites of
toxins or can determine best physical parameters for direct drug delivery and associated …

In this paper we present a mathematical and numerical model for human cardiac perfusion
which accounts for the different length scales of the vessels in the coronary tree. Epicardial …

Rationale: Endothelial dysfunction is of interest in relation to smoking-associated
emphysema, a component of chronic obstructive pulmonary disease (COPD). We previously …

Most existing whole lung models neglect the airway deformation kinematics and assume the
lung airways are static. However, neglecting the airway deformation effect on pulmonary air …

Assessing the toxicity of airborne particulate matter or the efficacy of inhaled drug depends
upon accurate estimates of deposited fraction of inhaled materials. In silico approaches can …

The purpose of this work was to explore the use of image registration-derived variables
associated with computed tomographic (CT) imaging of the lung acquired at multiple …