Protein identification strategies in MALDI imaging mass spectrometry: a brief review

DJ Ryan, JM Spraggins, RM Caprioli - Current opinion in chemical biology, 2019 - Elsevier
Matrix assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a
powerful technology used to investigate the spatial distributions of thousands of molecules …

Mass spectrometry imaging for clinical research–latest developments, applications, and current limitations

PM Vaysse, RMA Heeren, T Porta, B Balluff - Analyst, 2017 - pubs.rsc.org
Mass spectrometry is being used in many clinical research areas ranging from toxicology to
personalized medicine. Of all the mass spectrometry techniques, mass spectrometry …

Atmospheric pressure MALDI mass spectrometry imaging of tissues and cells at 1.4-μm lateral resolution

M Kompauer, S Heiles, B Spengler - Nature methods, 2017 - nature.com
We report an atmospheric pressure (AP) matrix-assisted laser desorption/ionization (MALDI)
mass spectrometry imaging (MSI) setup with a lateral resolution of 1.4 μm, a mass resolution …

[HTML][HTML] Automated mass spectrometry imaging of over 2000 proteins from tissue sections at 100-μm spatial resolution

PD Piehowski, Y Zhu, LM Bramer, KG Stratton… - Nature …, 2020 - nature.com
Biological tissues exhibit complex spatial heterogeneity that directs the functions of
multicellular organisms. Quantifying protein expression is essential for elucidating …

Ultra-high mass resolving power, mass accuracy, and dynamic range MALDI mass spectrometry imaging by 21-T FT-ICR MS

AP Bowman, GT Blakney, CL Hendrickson… - Analytical …, 2020 - ACS Publications
Detailed characterization of complex biological surfaces by matrix-assisted laser
desorption/ionization (MALDI) mass spectrometry imaging (MSI) requires instrumentation …

Ultra-high mass resolution MALDI imaging mass spectrometry of proteins and metabolites in a mouse model of glioblastoma

M Dilillo, R Ait-Belkacem, C Esteve, D Pellegrini… - Scientific reports, 2017 - nature.com
MALDI mass spectrometry imaging is able to simultaneously determine the spatial
distribution of hundreds of molecules directly from tissue sections, without labeling and …

Next‐generation technologies for spatial proteomics: integrating ultra‐high speed MALDI‐TOF and high mass resolution MALDI FTICR imaging mass spectrometry for …

JM Spraggins, DG Rizzo, JL Moore, MJ Noto… - …, 2016 - Wiley Online Library
MALDI imaging mass spectrometry is a powerful analytical tool enabling the visualization of
biomolecules in tissue. However, there are unique challenges associated with protein …

Mass spectrometry imaging for spatially resolved multi-omics molecular map**

H Zhang, KH Lu, M Ebbini, P Huang, H Lu, L Li - npj Imaging, 2024 - nature.com
The recent upswing in the integration of spatial multi-omics for conducting multidimensional
information measurements is opening a new chapter in biological research. Map** the …

Multimodal imaging based on vibrational spectroscopies and mass spectrometry imaging applied to biological tissue: a multiscale and multiomics review

M Tuck, L Blanc, R Touti, NH Patterson… - Analytical …, 2020 - ACS Publications
Molecular imaging has the potential to unearth important spatial and temporal relationships
in biological systems, including intercellular signaling as well as environmentally-cued …

Staphylococcus aureus exhibits heterogeneous siderophore production within the vertebrate host

WJ Perry, JM Spraggins, JR Sheldon… - Proceedings of the …, 2019 - National Acad Sciences
Siderophores, iron-scavenging small molecules, are fundamental to bacterial nutrient metal
acquisition and enable pathogens to overcome challenges imposed by nutritional immunity …