Artificial intelligence in drug development: present status and future prospects

KK Mak, MR Pichika - Drug discovery today, 2019 - Elsevier
Highlights•Advances in artificial intelligence (AI) are modernising several aspects of our
lives.•The pharma industry is facing challenges to overcome the high attrition rates in drug …

[HTML][HTML] Minimal clinically important differences in randomised clinical trials on pain management after total hip and knee arthroplasty: a systematic review

J Laigaard, C Pedersen, TN Rønsbo… - British journal of …, 2021 - Elsevier
Background Sample size determination is essential for reliable hypothesis testing in clinical
trials and should rely on adequate sample size calculations with alpha, beta, variance, and …

[HTML][HTML] Angiography after out-of-hospital cardiac arrest without ST-segment elevation

S Desch, A Freund, I Akin, M Behnes… - … England Journal of …, 2021 - Mass Medical Soc
Background Myocardial infarction is a frequent cause of out-of-hospital cardiac arrest.
However, the benefits of early coronary angiography and revascularization in resuscitated …

Sample size estimation in clinical research: from randomized controlled trials to observational studies

X Wang, X Ji - Chest, 2020 - Elsevier
Sample size determination is an essential step in planning a clinical study. It is critical to
understand that different study designs need different methods of sample size estimation …

[PDF][PDF] How to calculate sample size for observational and experimental nursing research studies

SK Sharma, SK Mudgal, K Thakur… - National Journal of …, 2020 - researchgate.net
Sample size estimation for a research study is the most crucial part of the research process
because it helps to produce reliable results which improve generalizability of study results. A …

Comparison of treatments for frozen shoulder: a systematic review and meta-analysis

D Challoumas, M Biddle, M McLean… - JAMA network …, 2020 - jamanetwork.com
Importance There are a myriad of available treatment options for patients with frozen
shoulder, which can be overwhelming to the treating health care professional. Objective To …

Guidelines for in vivo mouse models of myocardial infarction

ML Lindsey, KR Brunt, JA Kirk… - American Journal …, 2021 - journals.physiology.org
Despite significant improvements in reperfusion strategies, acute coronary syndromes all too
often culminate in a myocardial infarction (MI). The consequent MI can, in turn, lead to …

Yoga as a therapeutic intervention: a bibliometric analysis of published research studies from 1967 to 2013

PE Jeter, J Slutsky, N Singh… - The journal of alternative …, 2015 - liebertpub.com
Objective: A comprehensive bibliometric analysis was conducted on publications for yoga
therapy research in clinical populations. Methods: Major electronic databases were …

[HTML][HTML] Diabetes self-management smartphone application for adults with type 1 diabetes: randomized controlled trial

M Kirwan, C Vandelanotte, A Fenning… - Journal of medical Internet …, 2013 - jmir.org
Background Persistently poor glycemic control in adult type 1 diabetes patients is a
common, complex, and serious problem initiating significant damage to the cardiovascular …

Understanding type I and type II errors, statistical power and sample size

AK Akobeng - Acta Paediatrica, 2016 - Wiley Online Library
The results of a clinical trial may be subject to random error because of the variability in the
measured data, which arises purely by chance. There are two types of random error–type I …