Insulin resistance is the pivotal pathogenic component of many metabolic diseases,
including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of …

Insulin resistance, defined as a defect in insulin-mediated control of glucose metabolism in
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …

As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …

The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Diabetes, a complex multisystem metabolic disorder characterized by hyperglycemia, leads
to complications that reduce quality of life and increase mortality. Diabetes pathophysiology …

Insulin resistance is a main determinant in the development of type 2 diabetes mellitus and a
major cause of morbidity and mortality. The circadian timing system consists of a central …

Age-related loss of skeletal muscle mass and function, sarcopenia, is associated with
physical frailty and increased risk of morbidity (chronic diseases), in addition to all-cause …

Age is a primary risk factor for a number of chronic diseases including mobility disability,
cardiovascular disease (CVD), type 2 diabetes (T2D), and cancer. Most physical activity …

Patients with type 2 diabetes mellitus (T2DM) are at high risk for macrovascular
complications, which represent the major cause of mortality. Despite effective treatment of …

Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to
the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular …