Eosinophil knockout humans: uncovering the role of eosinophils through eosinophil-directed biological therapies
The enigmatic eosinophil has emerged as an exciting component of the immune system,
involved in a plethora of homeostatic and inflammatory responses. Substantial progress has …
involved in a plethora of homeostatic and inflammatory responses. Substantial progress has …
Tissue-dependent adaptations and functions of innate lymphoid cells
Tissue-resident immune cells reside in distinct niches across organs, where they contribute
to tissue homeostasis and rapidly respond to perturbations in the local microenvironment …
to tissue homeostasis and rapidly respond to perturbations in the local microenvironment …
Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation
Allergic immunity is orchestrated by group 2 innate lymphoid cells (ILC2s) and type 2 helper
T (Th2) cells prominently arrayed at epithelial-and microbial-rich barriers. However, ILC2s …
T (Th2) cells prominently arrayed at epithelial-and microbial-rich barriers. However, ILC2s …
IL-10 production by ILC2s requires Blimp-1 and cMaf, modulates cellular metabolism, and ameliorates airway hyperreactivity
Background Group 2 innate lymphoid cells (ILC2s) are the dominant innate lymphoid cell
population in the lungs at steady state, and their release of type 2 cytokines is a central …
population in the lungs at steady state, and their release of type 2 cytokines is a central …
Gut Microbial Metabolite Pravastatin Attenuates Intestinal Ischemia/Reperfusion Injury Through Promoting IL-13 Release From Type II Innate Lymphoid Cells via IL …
F Deng, JJ Hu, X Yang, QS Sun, ZB Lin… - Frontiers in …, 2021 - frontiersin.org
Intestinal ischemia/reperfusion (I/R) injury is a grave condition with high morbidity and
mortality. We previously confirmed that intestinal I/R induces intestinal flora disorders and …
mortality. We previously confirmed that intestinal I/R induces intestinal flora disorders and …
Interleukin (IL)‐33: an orchestrator of immunity from host defence to tissue homeostasis
Z Zhou, F Yan, O Liu - Clinical & Translational Immunology, 2020 - Wiley Online Library
Abstract Interleukin (IL)‐33, a member of the IL‐1 superfamily, functions as an alarm signal,
which is released upon cell injury or tissue damage to alert the immune system. It has …
which is released upon cell injury or tissue damage to alert the immune system. It has …
Lymphocytes: versatile participants in acute kidney injury and progression to chronic kidney disease
C Cao, Y Yao, R Zeng - Frontiers in Physiology, 2021 - frontiersin.org
Background: Acute kidney injury (AKI) remains a major global public health concern due to
its high morbidity and mortality. The progression from AKI to chronic kidney disease (CKD) …
its high morbidity and mortality. The progression from AKI to chronic kidney disease (CKD) …
The roles of kidney-resident ILC2 in renal inflammation and fibrosis
R Nagashima, M Iyoda - Frontiers in immunology, 2021 - frontiersin.org
Innate lymphoid cells (ILCs) are a recently discovered lymphocyte population with high
cytokine productive capacity. Type-2 ILCs (ILC2s) are the most studied, and they exert a …
cytokine productive capacity. Type-2 ILCs (ILC2s) are the most studied, and they exert a …
Protective and pathogenic functions of innate lymphoid cells in transplantation
Innate lymphoid cells (ILCs) are a family of lymphocytes with essential roles in tissue
homeostasis and immunity. Along with other tissue-resident immune populations, distinct …
homeostasis and immunity. Along with other tissue-resident immune populations, distinct …
ILC2s expanded by exogenous IL-33 regulate CD45+ CD11b+ F4/80high macrophage polarization to alleviate hepatic ischemia-reperfusion injury
HM Zhang, XJ Chen, SP Li, JM Zhang, J Sun… - Frontiers in …, 2022 - frontiersin.org
Hepatic ischemia-reperfusion injury (IRI) is an adverse consequence of hepatectomy or liver
transplantation. Recently, immune mechanisms involved in hepatic IRI have attracted …
transplantation. Recently, immune mechanisms involved in hepatic IRI have attracted …