Roles of transposable elements in the regulation of mammalian transcription
Transposable elements (TEs) comprise about half of the mammalian genome. TEs often
contain sequences capable of recruiting the host transcription machinery, which they use to …
contain sequences capable of recruiting the host transcription machinery, which they use to …
CRISPR technologies for precise epigenome editing
The epigenome involves a complex set of cellular processes governing genomic activity.
Dissecting this complexity necessitates the development of tools capable of specifically …
Dissecting this complexity necessitates the development of tools capable of specifically …
Enhancer–promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1
It remains unclear why acute depletion of CTCF (CCCTC-binding factor) and cohesin only
marginally affects expression of most genes despite substantially perturbing three …
marginally affects expression of most genes despite substantially perturbing three …
The relationship between genome structure and function
Precise patterns of gene expression in metazoans are controlled by three classes of
regulatory elements: promoters, enhancers and boundary elements. During differentiation …
regulatory elements: promoters, enhancers and boundary elements. During differentiation …
YY1-controlled regulatory connectivity and transcription are influenced by the cell cycle
Few transcription factors have been examined for their direct roles in physically connecting
enhancers and promoters. Here acute degradation of Yin Yang 1 (YY1) in erythroid cells …
enhancers and promoters. Here acute degradation of Yin Yang 1 (YY1) in erythroid cells …
In situ genome sequencing resolves DNA sequence and structure in intact biological samples
INTRODUCTION Genomes are spatially organized across length scales from single base
pairs to whole chromosomes. This organization is thought to regulate gene expression and …
pairs to whole chromosomes. This organization is thought to regulate gene expression and …
Identification of non-coding silencer elements and their regulation of gene expression
Cell type-and differentiation-specific gene expression is precisely controlled by genomic non-
coding regulatory elements (NCREs), which include promoters, enhancers, silencers and …
coding regulatory elements (NCREs), which include promoters, enhancers, silencers and …
Computational methods for analysing multiscale 3D genome organization
Recent progress in whole-genome map** and imaging technologies has enabled the
characterization of the spatial organization and folding of the genome in the nucleus. In …
characterization of the spatial organization and folding of the genome in the nucleus. In …
On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability
Expansions of simple tandem repeats are responsible for almost 50 human diseases, the
majority of which are severe, degenerative, and not currently treatable or preventable. In this …
majority of which are severe, degenerative, and not currently treatable or preventable. In this …
Lamina-associated domains: peripheral matters and internal affairs
At the nuclear periphery, associations of chromatin with the nuclear lamina through lamina-
associated domains (LADs) aid functional organization of the genome. We review the …
associated domains (LADs) aid functional organization of the genome. We review the …