Abstract Our previous International Union of Basic and Clinical Pharmacology report on the
nomenclature and classification of adenosine receptors (2011) contained a number of …

The discovery and clinical implementation of modulators of adenosine, P2Y and P2X
receptors (comprising nineteen subtypes) have progressed dramatically in∼ 50 years since …

Class BG protein-coupled receptors (GPCRs) are important targets in the treatment of
metabolic syndrome and diabetes. Although multiple structures of class B GPCRs–G protein …

Abstract Background and Purpose Allosterism is a regulatory mechanism for GPCRs that
can be attained by ligand‐binding or protein–protein interactions with another GPCR. We …

Adenosine is one of the most ancient signaling molecules and has receptors in both animals
and plants. In mammals there are four specific receptors, A 1, A 2A, A 2B, and A 3, which …

Cannabidiol (CBD), the second most abundant of the active compounds found in the
Cannabis sativa plant, is of increasing interest because it is approved for human use and is …

G protein-coupled receptors (GPCRs) exist within a landscape of interconvertible
conformational states and in dynamic equilibrium between monomers and higher-order …

Abstract (R, S)-methadone ((R, S)-MTD) is a µ-opioid receptor (MOR) agonist comprised of
(R)-MTD and (S)-MTD enantiomers.(S)-MTD is being developed as an antidepressant and is …

(−)-Δ9-trans-tetrahydrocannabinol (THC), which is the principal psychoactive constituent of
Cannabis, mediates its action by binding to two members of the G-protein-coupled receptor …

G protein-coupled receptors (GPCRs) are membrane proteins targeted by over one-third of
marketed drugs. Understanding their activation mechanism is essential for precise …