Hypertension—the chronic elevation of blood pressure—is a major human health problem.
In most cases, the root cause of the disease remains unknown, but there is mounting …

Hypertension is a complex condition and is the most common cardiovascular risk factor,
contributing to widespread morbidity and mortality. Approximately 90% of hypertension …

Emerging evidence suggests that gut microbiota is critical in the maintenance of
physiological homeostasis. This study was designed to test the hypothesis that dysbiosis in …

Background Renal sympathetic hyperactivity is associated with hypertension and its
progression, chronic kidney disease, and heart failure. We did a proof-of-principle trial of …

Background Renal denervation (RDN) with radiofrequency ablation substantially reduces
blood pressure in patients with treatment-resistant hypertension. We assessed the long-term …

To the Editor: The renal sympathetic nerves have been identified as a major contributor to
the complex pathophysiology of hypertension in both experimental models and in humans. 1 …

This review provides an outline of the association between major depressive disorder
(MDD) and coronary heart disease (CHD). Much is known about the two individual clinical …

This review examines how the sympathetic nervous system plays a major role in the
regulation of cardiovascular function over multiple time scales. This is achieved through …

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field
to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (eg …

Methods and apparatus are provided for non-continuous cir cumferential treatment of a body
lumen. Apparatus may be positioned within a body lumen of a patient and may deliver …