Artificial intelligence-enabled quantitative phase imaging methods for life sciences

J Park, B Bai, DH Ryu, T Liu, C Lee, Y Luo, MJ Lee… - Nature …, 2023 - nature.com
Quantitative phase imaging, integrated with artificial intelligence, allows for the rapid and
label-free investigation of the physiology and pathology of biological systems. This review …

Quantitative phase imaging based on holography: trends and new perspectives

Z Huang, L Cao - Light: Science & Applications, 2024 - nature.com
Abstract In 1948, Dennis Gabor proposed the concept of holography, providing a pioneering
solution to a quantitative description of the optical wavefront. After 75 years of development …

Quantitative phase imaging: recent advances and expanding potential in biomedicine

TL Nguyen, S Pradeep, RL Judson-Torres, J Reed… - ACS …, 2022 - ACS Publications
Quantitative phase imaging (QPI) is a label-free, wide-field microscopy approach with
significant opportunities for biomedical applications. QPI uses the natural phase shift of light …

On the use of deep learning for phase recovery

K Wang, L Song, C Wang, Z Ren, G Zhao… - Light: Science & …, 2024 - nature.com
Phase recovery (PR) refers to calculating the phase of the light field from its intensity
measurements. As exemplified from quantitative phase imaging and coherent diffraction …

Label-free multiplexed microtomography of endogenous subcellular dynamics using generalizable deep learning

YJ Jo, H Cho, WS Park, G Kim, DH Ryu, YS Kim… - Nature Cell …, 2021 - nature.com
Simultaneous imaging of various facets of intact biological systems across multiple
spatiotemporal scales is a long-standing goal in biology and medicine, for which progress is …

[HTML][HTML] Permittivity tensor imaging: modular label-free imaging of 3D dry mass and 3D orientation at high resolution

LH Yeh, IE Ivanov, T Chandler, JR Byrum, BB Chhun… - Nature …, 2024 - nature.com
The dry mass and the orientation of biomolecules can be imaged without a label by
measuring their permittivity tensor (PT), which describes how biomolecules affect the phase …

[HTML][HTML] Post mortem map** of connectional anatomy for the validation of diffusion MRI

A Yendiki, M Aggarwal, M Axer, AFD Howard… - NeuroImage, 2022 - Elsevier
Diffusion MRI (dMRI) is a unique tool for the study of brain circuitry, as it allows us to image
both the macroscopic trajectories and the microstructural properties of axon bundles in vivo …

Single-cell cytometry via multiplexed fluorescence prediction by label-free reflectance microscopy

S Cheng, S Fu, YM Kim, W Song, Y Li, Y Xue, J Yi… - Science …, 2021 - science.org
Traditional imaging cytometry uses fluorescence markers to identify specific structures but is
limited in throughput by the labeling process. We develop a label-free technique that …

Spatial light interference microscopy: principle and applications to biomedicine

X Chen, ME Kandel, G Popescu - Advances in optics and photonics, 2021 - opg.optica.org
In this paper, we review spatial light interference microscopy (SLIM), a common-path, phase-
shifting interferometer, built onto a phase-contrast microscope, with white-light illumination …

MesoNet allows automated scaling and segmentation of mouse mesoscale cortical maps using machine learning

D **ao, BJ Forys, MP Vanni, TH Murphy - Nature communications, 2021 - nature.com
Understanding the basis of brain function requires knowledge of cortical operations over
wide spatial scales and the quantitative analysis of brain activity in well-defined brain …