The biology of ergothioneine, an antioxidant nutraceutical

I Borodina, LC Kenny, CM McCarthy… - Nutrition Research …, 2020 - cambridge.org
Ergothioneine (ERG) is an unusual thio-histidine betaine amino acid that has potent
antioxidant activities. It is synthesised by a variety of microbes, especially fungi (including in …

Role of ergothioneine in microbial physiology and pathogenesis

BM Cumming, KC Chinta, VP Reddy… - Antioxidants & Redox …, 2018 - liebertpub.com
Significance: L-ergothioneine is synthesized in actinomycetes, cyanobacteria,
methylobacteria, and some fungi. In contrast to other low-molecular-weight redox buffers …

Discovery and structure of a widespread bacterial ABC transporter specific for ergothioneine

Y Zhang, G Gonzalez-Gutierrez, KA Legg… - Nature …, 2022 - nature.com
Abstract L-Ergothioneine (ET), the 2-thioimidazole derivative of trimethylhistidine, is
biosynthesized by select fungi and bacteria, notably Mycobacterium tuberculosis, and …

The entomopathogenic fungus Beauveria bassiana employs autophagy as a persistence and recovery mechanism during conidial dormancy

JL Ding, HY Lin, J Hou, MG Feng, SH Ying - MBio, 2023 - Am Soc Microbiol
Many filamentous fungi develop a conidiation process as an essential mechanism for their
dispersal and survival in natural ecosystems. However, the mechanisms underlying conidial …

Involvement of Sulfur in the Biosynthesis of Essential Metabolites in Pathogenic Fungi of Animals, Particularly Aspergillus spp.: Molecular and Therapeutic …

AM Traynor, KJ Sheridan, GW Jones… - Frontiers in …, 2019 - frontiersin.org
Fungal sulfur uptake is required for incorporation into the sidechains of the amino acids
cysteine and methionine, and is also essential for the biosynthesis of the antioxidant …

Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus

KJ Sheridan, BE Lechner, GO Keeffe, MA Keller… - Scientific Reports, 2016 - nature.com
Abstract Ergothioneine (EGT; 2-mercaptohistidine trimethylbetaine) is a trimethylated and
sulphurised histidine derivative which exhibits antioxidant properties. Here we report that …

Convergent evolution of ergothioneine biosynthesis in cyanobacteria

C Liao, FP Seebeck - ChemBioChem, 2017 - Wiley Online Library
Biosynthesis of N‐α‐trimethyl‐2‐thiohistidine (ergothioneine) is a frequent trait in
cyanobacteria. This sulfur compound may provide essential relief from oxidative stress …

Regulation of ergothioneine biosynthesis and its effect on Mycobacterium tuberculosis growth and infectivity

M Richard-Greenblatt, H Bach, J Adamson… - Journal of Biological …, 2015 - ASBMB
Ergothioneine (EGT) is synthesized in mycobacteria, but limited knowledge exists regarding
its synthesis, physiological role, and regulation. We have identified Rv3701c from …

Structure of the ergothioneine‐biosynthesis amidohydrolase EgtC

A Vit, GT Mashabela, W Blankenfeldt… - …, 2015 - Wiley Online Library
The ubiquitous sulfur metabolite ergothioneine is biosynthesized by oxidative attachment of
a sulfur atom to the imidazole ring of Nα‐trimethylhistidine. Most actinobacteria, including …

Control of Development, Secondary Metabolism and Light-Dependent Carotenoid Biosynthesis by the Velvet Complex of Neurospora crassa

ÖS Bayram, A Dettmann, B Karahoda, NM Moloney… - Genetics, 2019 - academic.oup.com
Neurospora crassa is an established reference organism to investigate carotene
biosynthesis and light regulation. However, there is little evidence of its capacity to produce …