The biology of ergothioneine, an antioxidant nutraceutical
Ergothioneine (ERG) is an unusual thio-histidine betaine amino acid that has potent
antioxidant activities. It is synthesised by a variety of microbes, especially fungi (including in …
antioxidant activities. It is synthesised by a variety of microbes, especially fungi (including in …
Role of ergothioneine in microbial physiology and pathogenesis
BM Cumming, KC Chinta, VP Reddy… - Antioxidants & Redox …, 2018 - liebertpub.com
Significance: L-ergothioneine is synthesized in actinomycetes, cyanobacteria,
methylobacteria, and some fungi. In contrast to other low-molecular-weight redox buffers …
methylobacteria, and some fungi. In contrast to other low-molecular-weight redox buffers …
Discovery and structure of a widespread bacterial ABC transporter specific for ergothioneine
Abstract L-Ergothioneine (ET), the 2-thioimidazole derivative of trimethylhistidine, is
biosynthesized by select fungi and bacteria, notably Mycobacterium tuberculosis, and …
biosynthesized by select fungi and bacteria, notably Mycobacterium tuberculosis, and …
The entomopathogenic fungus Beauveria bassiana employs autophagy as a persistence and recovery mechanism during conidial dormancy
JL Ding, HY Lin, J Hou, MG Feng, SH Ying - MBio, 2023 - Am Soc Microbiol
Many filamentous fungi develop a conidiation process as an essential mechanism for their
dispersal and survival in natural ecosystems. However, the mechanisms underlying conidial …
dispersal and survival in natural ecosystems. However, the mechanisms underlying conidial …
Involvement of Sulfur in the Biosynthesis of Essential Metabolites in Pathogenic Fungi of Animals, Particularly Aspergillus spp.: Molecular and Therapeutic …
AM Traynor, KJ Sheridan, GW Jones… - Frontiers in …, 2019 - frontiersin.org
Fungal sulfur uptake is required for incorporation into the sidechains of the amino acids
cysteine and methionine, and is also essential for the biosynthesis of the antioxidant …
cysteine and methionine, and is also essential for the biosynthesis of the antioxidant …
Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus
KJ Sheridan, BE Lechner, GO Keeffe, MA Keller… - Scientific Reports, 2016 - nature.com
Abstract Ergothioneine (EGT; 2-mercaptohistidine trimethylbetaine) is a trimethylated and
sulphurised histidine derivative which exhibits antioxidant properties. Here we report that …
sulphurised histidine derivative which exhibits antioxidant properties. Here we report that …
Convergent evolution of ergothioneine biosynthesis in cyanobacteria
C Liao, FP Seebeck - ChemBioChem, 2017 - Wiley Online Library
Biosynthesis of N‐α‐trimethyl‐2‐thiohistidine (ergothioneine) is a frequent trait in
cyanobacteria. This sulfur compound may provide essential relief from oxidative stress …
cyanobacteria. This sulfur compound may provide essential relief from oxidative stress …
Regulation of ergothioneine biosynthesis and its effect on Mycobacterium tuberculosis growth and infectivity
M Richard-Greenblatt, H Bach, J Adamson… - Journal of Biological …, 2015 - ASBMB
Ergothioneine (EGT) is synthesized in mycobacteria, but limited knowledge exists regarding
its synthesis, physiological role, and regulation. We have identified Rv3701c from …
its synthesis, physiological role, and regulation. We have identified Rv3701c from …
Structure of the ergothioneine‐biosynthesis amidohydrolase EgtC
A Vit, GT Mashabela, W Blankenfeldt… - …, 2015 - Wiley Online Library
The ubiquitous sulfur metabolite ergothioneine is biosynthesized by oxidative attachment of
a sulfur atom to the imidazole ring of Nα‐trimethylhistidine. Most actinobacteria, including …
a sulfur atom to the imidazole ring of Nα‐trimethylhistidine. Most actinobacteria, including …
Control of Development, Secondary Metabolism and Light-Dependent Carotenoid Biosynthesis by the Velvet Complex of Neurospora crassa
Neurospora crassa is an established reference organism to investigate carotene
biosynthesis and light regulation. However, there is little evidence of its capacity to produce …
biosynthesis and light regulation. However, there is little evidence of its capacity to produce …