Dissolution research started to develop about 100 years ago as a field of physical chemistry
and since then important progress has been made. However, explicit interest in drug related …

The application of physiologically based pharmacokinetic (PBPK) modeling has developed
rapidly within the pharmaceutical industry and is becoming an integral part of drug discovery …

The aim of this tutorial is to introduce the concept of physiologically based pharmacokinetic
(PBPK) modeling to individuals in the pharmaceutical industry who may be relatively new to …

Here, we compile the Biopharmaceutics Drug Disposition Classification System (BDDCS)
classification for 927 drugs, which include 30 active metabolites. Of the 897 parent drugs …

The aim of this tutorial is to introduce the fundamental concepts of physiologically based
pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their …

Poor drug solubility remains a significant and frequently encountered problem for
pharmaceutical scientists. The ability of lipid-based formulations to facilitate gastrointestinal …

The application of physiologically-based pharmacokinetic (PBPK) modeling is coming of
age in drug development and regulation, reflecting significant advances over the past 10 …

This article reviews the major physiological and physicochemical principles of the effect of
food and gastrointestinal (GI) pH on the absorption and bioavailability of oral drugs, and the …

A revised classification system for oral drugs was developed using the biopharmaceutics
classification system (BCS) as a starting point. The revised system is designed to have a …

Delivering drugs in a water-insoluble formulation is a critical matter in therapeutic drug
development. However, because a drug molecule has to be water soluble to be readily …