State-of-the-art local correlation methods enable affordable gold standard quantum chemistry for up to hundreds of atoms

PR Nagy - Chemical Science, 2024 - pubs.rsc.org
In this feature, we review the current capabilities of local electron correlation methods up to
the coupled cluster model with single, double, and perturbative triple excitations [CCSD (T)] …

Linear-scaling local natural orbital CCSD (T) approach for open-shell systems: Algorithms, benchmarks, and large-scale applications

PB Szabó, J Csóka, M Kállay… - Journal of Chemical …, 2023 - ACS Publications
The extension of the highly optimized local natural orbital (LNO) coupled cluster (CC) with
single-, double-, and perturbative triple excitations [LNO-CCSD (T)] method is presented for …

Pursuing the basis set limit of CCSD (T) non-covalent interaction energies for medium-sized complexes: case study on the S66 compilation

PR Nagy, L Gyevi-Nagy, BD Lőrincz, M Kállay - Molecular Physics, 2023 - Taylor & Francis
Our recently developed conventional, explicitly correlated, and local natural orbital (LNO)
based coupled cluster with single, double, and perturbative triple excitations [CCSD (T)] …

Theoretical Study of Stability and Electronic Characteristics in Various Complexes of Psoralen as an Anticancer Drug in Gas Phase, Water and CCl4 Solutions

M Mohammadi, M Mahinian… - Chemical Research in …, 2022 - Springer
The present research employs density functional theory (DFT) computations to analyze the
structure and energy of complexes formed by psoralen drug with alkali (Li+, Na+, K+) and …

Polarizable AMOEBA Model for Simulating Mg2+·Protein·Nucleotide Complexes

JM Delgado, PR Nagy, S Varma - Journal of Chemical Information …, 2023 - ACS Publications
Molecular mechanics (MM) simulations have the potential to provide detailed insights into
the mechanisms of enzymes that utilize nucleotides as cofactors. In most cases, the activities …

Inclusion of High-Field Target Data in AMOEBA's Calibration Improves Predictions of Protein–Ion Interactions

JA Delgado, V Wineman-Fisher, S Pandit… - Journal of chemical …, 2022 - ACS Publications
The reliability of molecular mechanics simulations to predict effects of ion binding to proteins
depends on their ability to simultaneously describe ion–protein, ion–water, and protein …

Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins

R Belle, JJAG Kamps, J Poater, K Kumar… - Communications …, 2022 - nature.com
N ε-Methylation of lysine residues in histones plays an essential role in the regulation of
eukaryotic transcription. The 'highest'methylation mark, N ε-trimethyllysine, is specifically …