Regenerative medicine and tissue engineering have emerged as a multidisciplinary
promising field in the quest to address the limitations of traditional medical approaches. One …

Despite the increasing global incidence of brain disorders, achieving sufficient delivery
towards the central nervous system (CNS) remains a formidable challenge in terms of …

Gastroesophageal Reflux Disease (GERD) is a chronic ailment that results from the
backward flow of stomach acid into the esophagus, causing heartburn and acid …

The present work focuses on the development of surface modified transferrin PLGA
nanoparticles loaded with clonidine for nose to brain delivery. The CLD-Tf-PLGA-NPs were …

Glioblastoma (GBM) represents a formidable challenge in oncology, characterized by
aggressive proliferation and poor prognosis. Iron metabolism plays a critical player in GBM …

Paracellular permeability across epithelial and endothelial cells is, in large part, regulated
by apical intercellular junctions also referred to as tight junctions (TJs). These junctions …

We overviewed the anatomy and physiology of the nose-to-brain pathway, along with the
mechanisms involved. We then summarized the interaction process between nanoparticles …

In recent decades, biotechnological drugs have emerged as relevant therapeutic tools.
However, therapeutic molecules can exert their activity only if properly formulated and …

Three-dimensional bioprinting leverages computer-aided design to construct tissues and
organs with specialized bioinks. A notable biomaterial for this purpose is chitosan, a natural …

The increase in the variety of nano-based tools offers new possibilities to approach the
therapy of poorly treatable tumors, which includes glioblastoma multiforme (GBM; a primary …